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Urinary Excretion of Amines in Phenylketonuria and Mongolism

Perry, Thomas L. (1962) Urinary Excretion of Amines in Phenylketonuria and Mongolism. Science, 136 (3519). pp. 879-880. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20151209-151747340

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Abstract

Children with phenylketonuria excrete considerably less serotonin and tryptamine and somewhat less normetanephrine and p-tyramine than normal children. The excretion of these amines was not decreased in mongolism. Even during monoamine oxidase blockade, o-tyramine could not be detected in the urine of phenylketonurics. These findings are discussed in relation to the mental defect of phenylketonuria.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.136.3519.879DOIArticle
http://www.sciencemag.org/content/136/3519/879.abstractPublisherArticle
http://www.jstor.org/stable/1709221JSTORArticle
Additional Information:© 1962 American Association for the Advancement of Science. 22 December 1961. I am grateful to Dr. Dorothy Redlich for valuable assistance, and to Dr. Kenneth N. F. Shaw for helpful advice. This research was supported by grants from the Ford Foundation and from the National Institutes of Health. This report is contribution No. 2794 of California Institute of Technology, Pasadena.
Funders:
Funding AgencyGrant Number
Ford FoundationUNSPECIFIED
NIHUNSPECIFIED
Other Numbering System:
Other Numbering System NameOther Numbering System ID
Caltech Division of Chemistry and Chemical Engineering2794
Issue or Number:3519
Record Number:CaltechAUTHORS:20151209-151747340
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151209-151747340
Official Citation:Urinary Excretion of Amines in Phenylketonuria and Mongolism Thomas L. Perry Science 8 June 1962: 879-880.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62756
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:10 Dec 2015 20:59
Last Modified:03 Oct 2019 09:21

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