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Inhibition of Photoperiodic Induction by 5-Fluorouracil

Salisbury, Frank B. and Bonner, James (1960) Inhibition of Photoperiodic Induction by 5-Fluorouracil. Plant Physiology, 35 (2). pp. 173-177. ISSN 0032-0889. PMCID PMC405938. http://resolver.caltech.edu/CaltechAUTHORS:20151210-083053064

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Abstract

In this paper it will be shown that photoperiodic induction of the cocklebur, a short day plant, is inhibited by the pyrimidine 5-fluorouracil ( 5-FU). The studies of other workers have shown that 5-FU inhibits the growth of various kinds of cells and tissues by suppressing the formation of thymidine, and that application of thymidine relieves the inhibitory effects of 5-FU. In these cases 5-FU is an inhibitor of DNA synthesis (2, 4, 5). In other cases, however, 5-FU inhibits RNA synthesis. Thus 5-FU inhibits the production of tobacco mosaic viral RNA by tobacco leaves ( 1). This inhibition, which is relieved neither by thymidine nor by uracil, is associated with incorporation of 5-FU into the viral RNA (3). In. hibition of photoperiodic induction by 5-FU is not reversed by either thymidine or uracil but is reversed by orotic acid (6) which is known to be an intermediate in the biogenesis both of uridine and cytidine and of deoxycytidine and thymidine. Reversal of 5-FU inhibition by orotic acid suggests the hypothesis that the inhibition is related in some way to suppression of nucleic acid metabolism.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1104/pp.35.2.173DOIArticle
http://www.plantphysiol.org/content/35/2/173.full.pdf+htmlPublisherArticle
http://www.jstor.org/stable/4259557JSTORArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC405938/PubMed CentralArticle
Additional Information:© 1960 American Society of Plant Biologists. Received June 3, 1959. Supported in part by grants from the Frasch Foundation, National Science Foundation, and the Colorado State University Research Foundation. This work was reported at the Annual Meeting, American Society of Plant Physiologists, Indiana University. August, 1958. The authors gratefully acknowledge the able technical assistance of Pauline Christiansen.
Funders:
Funding AgencyGrant Number
Frasch FoundationUNSPECIFIED
NSFUNSPECIFIED
Colorado State University Research FoundationUNSPECIFIED
PubMed Central ID:PMC405938
Record Number:CaltechAUTHORS:20151210-083053064
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20151210-083053064
Official Citation:Frank B. Salisbury and James Bonner Inhibition of Photoperiodic Induction by 5-Fluorouracil Plant Physiol. March 1960 35: 173-177. doi:10.1104/pp.35.2.173
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62770
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:10 Dec 2015 20:32
Last Modified:10 Dec 2015 20:32

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