Phillips, M. Ian and Olds, James (1969) Unit Activity: Motivation-Dependent Responses from Midbrain Neurons. Science, 165 (3899). pp. 1269-1271. ISSN 0036-8075. doi:10.1126/science.165.3899.1269. https://resolver.caltech.edu/CaltechAUTHORS:20151211-151926584
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Abstract
Single neurons in the midbrain tegmentum of rats showed clear discriminatory responses to three tones announcing either food or water or no reinforcement. Subjects were required to press a single lever and remain motionless for 2 seconds during which time unit activity from several brain sites was recorded. One of the tones, randomly designated, was sounded halfway through this period. Manipulation of drive states revealed that the highest activity was associated with tones announcing the reinforcement for which the animal was most strongly motivated. Thus, from a hungry animal sustained or increased firing rates were elicited by a " food" tone and differentially lowered rates by the other tones.
Item Type: | Article | ||||||||||||
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Additional Information: | © 1969 American Association for the Advancement of Science. Received 3 June 1969. The experiment was carried out while we were at the Brain Research Laboratory, Department of Psychology, University of Michigan. Supported by grants from PHS. We thank P. J . Best and J. Rosenberg for computer programming and W. Allan, G. Baldrighi, W. Wetzel, and J. Frey for their technical assistance. | ||||||||||||
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Issue or Number: | 3899 | ||||||||||||
DOI: | 10.1126/science.165.3899.1269 | ||||||||||||
Record Number: | CaltechAUTHORS:20151211-151926584 | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20151211-151926584 | ||||||||||||
Official Citation: | Unit Activity: Motivation-Dependent Responses from Midbrain Neurons M. Ian Phillips and James Olds Science 19 September 1969: 165 (3899), 1269-1271. [DOI:10.1126/science.165.3899.1269] | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 62824 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Tony Diaz | ||||||||||||
Deposited On: | 12 Dec 2015 00:01 | ||||||||||||
Last Modified: | 10 Nov 2021 23:07 |
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