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Unit Activity: Motivation-Dependent Responses from Midbrain Neurons

Phillips, M. Ian and Olds, James (1969) Unit Activity: Motivation-Dependent Responses from Midbrain Neurons. Science, 165 (3899). pp. 1269-1271. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20151211-151926584

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Abstract

Single neurons in the midbrain tegmentum of rats showed clear discriminatory responses to three tones announcing either food or water or no reinforcement. Subjects were required to press a single lever and remain motionless for 2 seconds during which time unit activity from several brain sites was recorded. One of the tones, randomly designated, was sounded halfway through this period. Manipulation of drive states revealed that the highest activity was associated with tones announcing the reinforcement for which the animal was most strongly motivated. Thus, from a hungry animal sustained or increased firing rates were elicited by a " food" tone and differentially lowered rates by the other tones.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.165.3899.1269DOIArticle
http://www.sciencemag.org/content/165/3899/1269PublisherArticle
http://www.jstor.org/stable/1727990JSTORArticle
Additional Information:© 1969 American Association for the Advancement of Science. Received 3 June 1969. The experiment was carried out while we were at the Brain Research Laboratory, Department of Psychology, University of Michigan. Supported by grants from PHS. We thank P. J . Best and J. Rosenberg for computer programming and W. Allan, G. Baldrighi, W. Wetzel, and J. Frey for their technical assistance.
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)UNSPECIFIED
Issue or Number:3899
Record Number:CaltechAUTHORS:20151211-151926584
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151211-151926584
Official Citation:Unit Activity: Motivation-Dependent Responses from Midbrain Neurons M. Ian Phillips and James Olds Science 19 September 1969: 165 (3899), 1269-1271. [DOI:10.1126/science.165.3899.1269]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62824
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Dec 2015 00:01
Last Modified:03 Oct 2019 09:22

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