Kerr, Ian M. and Olshevsky, Udy and Lodish, Harvey F. and Baltimore, David (1976) Translation of murine leukemia virus RNA in cell-free systems from animal cells. Journal of Virology, 18 (2). pp. 627-635. ISSN 0022-538X. PMCID PMC515589. doi:10.1128/jvi.18.2.627-635.1976. https://resolver.caltech.edu/CaltechAUTHORS:KERjvir76
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Abstract
The virion RNA of Moloney murine leukemia virus (MuLV) has been translated in eukaryotic cell-free systems derived from mouse L- and human HeLa cells. In both systems at least three polypeptides, approximately 60,000, 70,000, and 180,000 in apparent molecular weight, were formed in response to the added 35S MuLV RNA. All three polypeptides were precipitable with antiserum to detergent-disrupted MuLV. Fingerprint analysis of tryptic digests indicated that all three contain anino acid sequences in common with each other and with the major methionine-containing structural proteins of the virion.
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| Additional Information: | © 1976 American Society for Microbiology. Received for publication 8 December 1975 This work was supported by an American Cancer Society Eleanor Roosevelt Cancer Research Fellowship to I.M.K., by U.S. Public Health Service International Fellowship F0-5-TW-2135 to U.O., and by Public Health Service grants CA 14051 and AI 08814 from the National Cancer Institute and from the National Institute of Allergy and Infectious Diseases, respectively. D.B. and H.F.L. were recipients of grants VC-4G and NP-180 from the American Cancer Society. D.B. is an American Cancer Society Professor, and H.F.L. is the recipient of N.I.H. Research Career Development award 5-K04-GM50175. | ||||||||||||||
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| Issue or Number: | 2 | ||||||||||||||
| PubMed Central ID: | PMC515589 | ||||||||||||||
| DOI: | 10.1128/jvi.18.2.627-635.1976 | ||||||||||||||
| Record Number: | CaltechAUTHORS:KERjvir76 | ||||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:KERjvir76 | ||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||
| ID Code: | 6283 | ||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||
| Deposited By: | Archive Administrator | ||||||||||||||
| Deposited On: | 30 Nov 2006 | ||||||||||||||
| Last Modified: | 08 Nov 2021 20:32 |
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