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Measurement of Anesthetic Potency

Fenichel, I. Robert and Horowitz, Samuel B. and Cherkin, Arthur and Catchpool, J. F. (1966) Measurement of Anesthetic Potency. Science, 152 (3725). pp. 1110-1111. ISSN 0036-8075. doi:10.1126/science.152.3725.1110.

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In "Temperature dependence of anesthesia in goldfish" (l), Cherkin and Catchpool introduce a technique for making quantitative measurements of the anesthetic potency of water-soluble agents. Goldfish are kept swimming by an applied stimulus (an electric shock); anesthetic potency is measured as AD_(50) the dose at which 50 percent of the experimental animals fail to respond to the stimulus.

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Additional Information:© 1966 American Association for the Advancement of Science. 27 October 1965. Supported in part by NSF grant GB 3109 and PHS grant GM 11070.
Funding AgencyGrant Number
NSFGB 3109
U.S. Public Health Service (USPHS)GM-11070
Issue or Number:3725
Record Number:CaltechAUTHORS:20151214-071458387
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Official Citation:Measurement of Anesthetic Potency I. Robert Fenichel, Samuel B. Horowitz, Arthur Cherkin, and J. F. Catchpool Science 20 May 1966: 152 (3725), 1110-1111. [DOI:10.1126/science.152.3725.1110]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62833
Deposited By: Ruth Sustaita
Deposited On:14 Dec 2015 17:42
Last Modified:10 Nov 2021 23:07

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