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Mechanism of Antibody Synthesis: Size Differences between Mouse Kappa Chains

Gray, William R. and Dreyer, William J. and Hood, Leroy (1967) Mechanism of Antibody Synthesis: Size Differences between Mouse Kappa Chains. Science, 155 (3761). pp. 465-467. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20151214-100808270

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Abstract

Structural analysis of immunoglobulin light chains has been carried out in an attempt to elucidate the genetic mechanisms involved in antibody synthesis. Analysis of two mouse kappa-chain proteins is almost complete. The differences are localized in one-half of the molecules, and do not reflect the operation of any one mutational mechanism. The peculiar character of the differences is discussed with reference to various theories of antibody formation. The finding that the two proteins differ in size is incompatible with certain proposed theories.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.155.3761.465DOIArticle
http://www.sciencemag.org/content/155/3761/465.abstractPublisherArticle
http://www.jstor.org/stable/1720205JSTORArticle
ORCID:
AuthorORCID
Hood, Leroy0000-0001-7158-3678
Additional Information:© 1967 American Association for the Advancement of Science. 21 November 1966. We thank J. Smith, U. Heidrich, and J. Raes for technical assistance. Supported by USPHS research grant GM-0-6965 and USPHS postdoctoral fellowship (1-F2-GM-20, 388-02) (L.H.).
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)GM-0-6965
U.S. Public Health Service (USPHS) Postdoctoral Fellow1-F2-GM-20
Record Number:CaltechAUTHORS:20151214-100808270
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20151214-100808270
Official Citation:Mechanism of Antibody Synthesis: Size Differences between Mouse Kappa Chains William R. Gray, William J. Dreyer, and Leroy Hood Science 27 January 1967: 155 (3761), 465-467. [DOI:10.1126/science.155.3761.465]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62853
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:14 Dec 2015 18:43
Last Modified:14 Dec 2015 18:43

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