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Membrane function and vascular reactivity

Bing, R. J. and Termin, A. and Conforto, A. and Dudek, R. and Hoffmann, M. J. (1993) Membrane function and vascular reactivity. Bioscience Reports, 13 (2). pp. 61-67. ISSN 0144-8463.

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This communication examines the possibility that nitric oxide (NO) production by endothelial cells results from changes in cell membrane fluidity. Lysophosphatidylcholine (LPC) alters fluidity of the endothelial cell membranes causing vascular relaxation. Through membrane alterations LPC influences function of a number of membrane receptors and modulates enzyme activity. As a result of detergent action, lysophosphatidylcholine (LPC) causes activation of guanylate cyclase, stimulates syalytransferase and regulates protein kinase C activity. It has already been demonstrated that ionic detergents, such as Triton X-100 also cause vascular relaxation, possibly induced by NO production from endothelial cells. It is postulated that production of nitric oxide results from changes in membrane viscosity; this may represent a mechanism for its regulation in biological systems.

Item Type:Article
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URLURL TypeDescription DOIArticle
Hoffmann, M. J.0000-0001-6495-1946
Additional Information:© 1993 Plenum Publishing Corporation. Received January 4, 1993. This work was supported by grants from The Council for Tobacco Research, NY; The Herbert J. and Margaret W. Hoover Foundation, Pasadena, CA; The Patron Saint Foundation, Pasadena, CA and Miles Corporation, West Haven, CT. We wish to acknowledge A. Alegria and M. Vanasco for their technical assistance as well as L. DeChaine for her secretarial help.
Funding AgencyGrant Number
Council for Tobacco ResearchUNSPECIFIED
Herbert J. and Margaret W. Hoover FoundationUNSPECIFIED
Patron Saint FoundationUNSPECIFIED
Miles CorporationUNSPECIFIED
Subject Keywords:Nitric oxide; membrane function; lysophosphatidylcholine
Issue or Number:2
Record Number:CaltechAUTHORS:20151214-155602204
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62906
Deposited By: Tony Diaz
Deposited On:15 Dec 2015 00:07
Last Modified:03 Mar 2020 13:01

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