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Poly(A) RNA of the Egg Cytoplasm: Structural Resemblance to the Nuclear RNA of Somatic Cells

Davidson, Eric H. and Jacobs, Howard T. and Thomas, Terry L. and Hough-Evans, Barbara R. and Britten, Roy J. (1983) Poly(A) RNA of the Egg Cytoplasm: Structural Resemblance to the Nuclear RNA of Somatic Cells. In: Molecular Biology of Egg Maturation. Ciba Foundation Symposium. No.98. Wiley , New York, NY, pp. 6-24. ISBN 9780272797303. https://resolver.caltech.edu/CaltechAUTHORS:20151217-181955149

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Abstract

This paper concerns the structural characteristics of the poly(A) RNA stored in unfertilized amphibian and echinoderm eggs. Though located in the egg cytoplasm, at least two-thirds of these maternal transcripts display an interspersed sequence organization similar to that of nuclear RNA. In Xenopus laevis interspersed poly(A) RNA molecules are synthesized and deposited in the oocyte cytoplasm throughout the main growth phase of oogenesis. Regions of the sea urchin genome that are represented by interspersed maternal transcripts have been recovered from recombinant clone libraries. In one case the same single-copy sequence is found both in an abundant message-sized 1.6 kilobase (kb) maternal transcript and in a 7.5 kb maternal transcript that structurally resembles a precursor form and is not found in embryonic polysomes. In a second example considered, a 9.5 kb transcript was identified in embryo nuclear RNA that may be identical in structure with an interspersed maternal poly(A) RNA derived from the same transcription unit. Transcription of this sequence appears to be constitutive in somatic cell nuclei, though no homologous cytoplasmic RNAs are found after early cleavage. This may be a widespread form of regulation for transcription units expressed in female germ cells, and represented in the maternal poly(A) RNA pools of unfertilized eggs.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/9780470720790.ch2DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/9780470720790.ch2/summaryPublisherArticle
Additional Information:© 1983 Ciba Foundation.
Subject Keywords:egg cytoplasm; somatic cells; echinoderm eggs; maternal transcripts; nuclear RNA
Series Name:Ciba Foundation Symposium
Issue or Number:98
Record Number:CaltechAUTHORS:20151217-181955149
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151217-181955149
Official Citation:Davidson, E. H., Jacobs, H. T., Thomas, T. L., Hough-Evans, B. R. and Britten, R. J. (1983) Poly(A) RNA of the Egg Cytoplasm: Structural Resemblance to the Nuclear RNA of Somatic Cells, in Ciba Foundation Symposium 98 - Molecular Biology of Egg Maturation (eds R. Porter and J. Whelan), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470720790.ch2
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63050
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:24 Feb 2016 22:50
Last Modified:03 Oct 2019 09:24

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