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A neuronal circuit for colour vision based on rod–cone opponency

Joesch, Maximilian and Meister, Markus (2016) A neuronal circuit for colour vision based on rod–cone opponency. Nature, 532 (7598). pp. 236-239. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20151223-110847966

[img] Image (JPEG) (Extended Data Figure 1: Spiking responses to chromatic centre and surround stimuli) - Supplemental Material
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[img] Image (JPEG) (Extended Data Figure 2: Spectra of the visual stimuli) - Supplemental Material
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[img] Image (JPEG) (Extended Data Figure 3: Responses of non-opponent J-RGCs in dorsal retina) - Supplemental Material
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[img] Image (JPEG) (Extended Data Figure 4: J-RGC current responses to flashed spots and annuli) - Supplemental Material
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[img] Image (JPEG) (Extended Data Figure 5: Synaptic pathways for spectral opponency (single cell examples)) - Supplemental Material
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[img] Image (JPEG) (Extended Data Figure 6: J-RGCs in a mutant retina with silenced cones) - Supplemental Material
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[img] Image (JPEG) (Extended Data Figure 7: Spectrally opponent features in the environment) - Supplemental Material
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[img] Image (JPEG) (Extended Data Figure 8: UV-green colour signature of urine) - Supplemental Material
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[img] Image (JPEG) (Extended Data Figure 9: Effects of the light flash exposure for fluorescent targeting) - Supplemental Material
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Abstract

In bright light, cone-photoreceptors are active and colour vision derives from a comparison of signals in cones with different visual pigments. This comparison begins in the retina, where certain retinal ganglion cells have ‘colour-opponent’ visual responses—excited by light of one colour and suppressed by another colour. In dim light, rod-photoreceptors are active, but colour vision is impossible because they all use the same visual pigment. Instead, the rod signals are thought to splice into retinal circuits at various points, in synergy with the cone signals. Here we report a new circuit for colour vision that challenges these expectations. A genetically identified type of mouse retinal ganglion cell called JAMB (J-RGC), was found to have colour-opponent responses, OFF to ultraviolet (UV) light and ON to green light. Although the mouse retina contains a green-sensitive cone, the ON response instead originates in rods. Rods and cones both contribute to the response over several decades of light intensity. Remarkably, the rod signal in this circuit is antagonistic to that from cones. For rodents, this UV-green channel may play a role in social communication, as suggested by spectral measurements from the environment. In the human retina, all of the components for this circuit exist as well, and its function can explain certain experiences of colour in dim lights, such as a ‘blue shift’ in twilight. The discovery of this genetically defined pathway will enable new targeted studies of colour processing in the brain.


Item Type:Article
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http://dx.doi.org/10.1038/nature17158DOIArticle
http://www.nature.com/nature/journal/v532/n7598/abs/nature17158.htmlPublisherArticle
http://rdcu.be/haOIPublisherFree ReadCube access
ORCID:
AuthorORCID
Meister, Markus0000-0003-2136-6506
Alternate Title:A Neuronal Circuit for Color Vision based on Rod-Cone Opponency
Additional Information:© 2016 Macmillan Publishers Limited. Received 29 March 2015. Accepted 21 January 2016. Published online 06 April 2016. We thank E. Soucy and J. Greenwood for technical support, J. Cauceglia for providing the urine post samples, J. R. Sanes and E. Soucy for comments on the manuscript. This work was supported by grants to M.M. from the NIH and to M.J. from The International Human Frontier Science Program Organization. Author Contributions: M.J. designed the study, performed all experiments, interpreted results, and wrote the manuscript. M.M. helped design the study, interpret results, and wrote the manuscript. The authors declare no competing financial interests.
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Funding AgencyGrant Number
NIHUNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Issue or Number:7598
Record Number:CaltechAUTHORS:20151223-110847966
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151223-110847966
Official Citation:A neuronal circuit for colour vision based on rod–cone opponency Maximilian Joesch & Markus Meister Nature 532, 236–239 (14 April 2016) doi:10.1038/nature17158
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63183
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:06 Apr 2016 18:36
Last Modified:03 Oct 2019 09:26

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