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Repeated Sequence Target Sites for Maternal DNA-Binding Proteins in Genes Activated in Early Sea Urchin Development

Anderson, Roger and Britten, Roy J. and Davidson, Eric H. (1994) Repeated Sequence Target Sites for Maternal DNA-Binding Proteins in Genes Activated in Early Sea Urchin Development. Developmental Biology, 163 (1). pp. 11-18. ISSN 0012-1606. https://resolver.caltech.edu/CaltechAUTHORS:20151223-111411934

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Abstract

This communication concerns a very highly conserved inverted repeat sequence element that serves as a target site for a sea urchin maternal DNA-binding factor. The maternal factor is present in relatively large amounts in unfertilized eggs, but is about 100× less prevalent per embryo in 24-hr embryo nuclear extract. The inverted repeat target site is found in the regulatory domain of the CyIIIa cytoskeletal actin gene and also in two upstream genes encoding transcriptions factors that bind to a functionally important cis-regulatory element of the CyIIIa gene. There are about 460 copies of the inverted repeat target site per genome. About 15% of these sites occur in a nested arrangement together with a second inverted repeat that binds another previously characterized maternal transcription factor. This arrangement is the same as that which occurs in the CyIIIa gene, and it may be of regulatory significance with respect to activation of certain genes in oogenesis and early embryogenesis.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1006/dbio.1994.1119 DOIArticle
http://www.sciencedirect.com/science/article/pii/S0012160684711195PublisherArticle
Additional Information:© 1994 by Academic Press, Inc. Accepted January 26, 1994. We thank Dr. Frank J. Calzone for providing egg and embryo extracts and Ms. Mary Chen for technical assistance. We are most appreciative of the efforts of Professor Carl Parker of this Institute who reviewed a draft of the manuscript. Research was supported by NIH Grant HD-05753. R.A. was supported by NIH Training Grant GM-07616.
Funders:
Funding AgencyGrant Number
NIHHD-05753
NIHGM-07616
Issue or Number:1
Record Number:CaltechAUTHORS:20151223-111411934
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151223-111411934
Official Citation:Roger Anderson, Roy J. Britten, Eric H. Davidson, Repeated Sequence Target Sites for Maternal DNA-Binding Proteins in Genes Activated in Early Sea Urchin Development, Developmental Biology, Volume 163, Issue 1, May 1994, Pages 11-18, ISSN 0012-1606, http://dx.doi.org/10.1006/dbio.1994.1119. (http://www.sciencedirect.com/science/article/pii/S0012160684711195)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63184
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Dec 2015 19:19
Last Modified:03 Oct 2019 09:26

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