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Lipopolysaccharide activates the sea urchin immune system

Smith, L. Courtney and Britten, Roy J. and Davidson, Eric H. (1995) Lipopolysaccharide activates the sea urchin immune system. Developmental and Comparative Immunology, 19 (3). pp. 217-224. ISSN 0145-305X. doi:10.1016/0145-305X(95)00009-I.

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Profilin is a small, actin-binding protein that functions at the intersection of signal transduction and cytoskeletal modifications. Increases in the number of profilin messages per cell correlate with sea urchin coelomocyte activation in response to injury. Here we show that coelomocytes respond to immune challenge from lipopolysaccharide with significant elevations in profilin transcripts per coelomocyte.

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Additional Information:© 1995 Elsevier. (Submitted February 1995; accepted April 1995) The authors wish to acknowledge the useful comments of the anonymous reviewers. This work was supported by a grant from NSF (No. MCB 9219330).
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Subject Keywords:Sea urchin; Strongylocentrotus purpuratus; Coelomocyte activation; Profilin; LPS
Issue or Number:3
Record Number:CaltechAUTHORS:20151223-141054015
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Official Citation:L. Courtney Smith, Roy J. Britten, Eric H. Davidson, Lipopolysaccharide activates the sea urchin immune system, Developmental & Comparative Immunology, Volume 19, Issue 3, May–June 1995, Pages 217-224, ISSN 0145-305X, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63200
Deposited By: George Porter
Deposited On:26 Feb 2016 15:38
Last Modified:10 Nov 2021 23:13

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