CaltechAUTHORS
  A Caltech Library Service

The role of non-neuronal cells in the development of sympathetically derived neurons

Patterson, Paul H. and Chun, Linda L. Y. and Reichardt, Louis F. (1977) The role of non-neuronal cells in the development of sympathetically derived neurons. In: Cellular Neurobiology. Progress in Clinical and Biological Research. No.15. Alan R. Liss , New York, pp. 95-103. ISBN 9780845100158. http://resolver.caltech.edu/CaltechAUTHORS:20151229-143725302

Full text is not posted in this repository.

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20151229-143725302

Abstract

As other speakers in this session have discussed, a variety of influences are brought to bear on presumptive sympathetic neurons during their migration and subsequent differentiation. Some of these other influences, namely nerve growth factor (NGF) and electrical activity, continue to affect the functional state of these neurons even in the adult. These studies have involved axotomy, decentralization, transplantation in embryos, or explantation to the anterior chamber of the eye, to the chorioallantoic membrane, or to organ culture. Yet another approach has been to dissociate the neurons and grow them in cell culture. Investigation of their development in the absence of other cell types or in the presence of added cells of known origin then contributed information about the relative importance of such cellular influences as well as their mechanism of action. The potential for controlling the fluid environment as well as the substratum on which the cells are grown may also be exploited to yield information about normal development.


Item Type:Book Section
Additional Information:© 1977 Alan R. Liss, Inc. It is a pleasure to acknowledge the able assistance of Doreen McDowell, Karen Fischer, and Kathy Birmingham with the culturing. We also thank Eleanor P. Livingston and Joe Gagliardi for excellent help with the manuscript. This work was supported by an American Heart Association Grant-in-Aid (73-877) and a United States Public Health Service Grant (1 RO1 NS 11027) from the National Institute of Neurological and Communicable Diseases and Stroke. Paul H. Patterson is a Research Career Development Awardee of the N.I.N.C.D.S. (1 K04 NS 70806); Louis F. Reichardt has been a postdoctoral fellow of the N.I.N.C.D.S. (1 F22 NS 01784), Jane Coffin Childs Memorial Fund for Medical Research, and the Medical Foundation; and Linda L. Y. Chun is a Public Health Service Trainee (TO1 NS 05731).
Funders:
Funding AgencyGrant Number
American Heart Association73-877
National Institute of Neurological and Communicable Diseases and Stroke (NINCDS)1 RO1 NS 11027
National Institute of Neurological and Communicable Diseases and Stroke (NINCDS)1 K04 NS 70806
National Institute of Neurological and Communicable Diseases and Stroke (NINCDS)1 F22 NS 01784
NIH Postdoctoral FellowshipUNSPECIFIED
Jane Coffin Childs Memorial Fund for Medical ResearchUNSPECIFIED
Medical FoundationUNSPECIFIED
U.S. Public Health Service (USPHS)TO1 NS 05731
Record Number:CaltechAUTHORS:20151229-143725302
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20151229-143725302
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63247
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:24 Feb 2016 22:28
Last Modified:13 Feb 2019 18:06

Repository Staff Only: item control page