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Adrenal chromaffin cells as multipotential neurons for autografts

Mahanthappa, Nagesh K. and Gage, Fred H. and Patterson, Paul H. (1990) Adrenal chromaffin cells as multipotential neurons for autografts. In: Progress in Brain Research. Vol.82. Academic Press , New York, NY, pp. 33-39. ISBN 978-0-444-81137-0.

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The chromaffin cell grafts in the Parkinsonism models is used primarily as the living depots of catecholamines. Because of their phenotypic plasticity, however, chromaffin cells have considerably more potential as donor tissue than has been utilized heretofore. These cells can be maintained in their normal chromaffin phenotype by the addition of corticosteroids, and they can grow neurites when the steroid is removed and nerve growth factor (NGF) or fibroblast growth factor (FGF) is added. Moreover, when the appropriate conditioned medium (CM) is supplied along with NGF, the efficiency of conversion of neonatal chromaffin cells into sympathetic neurons is enhanced and chromaffin cells taken from adult rats can also be converted. In addition, the chromaffin cell-derived neurons can be converted to the cholinergic phenotype when an instructive differentiation factor purified from cultured heart cells is added. These converted, cholinergic sympathetic neurons can form functional cholinergic synapses.

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Additional Information:© 1990 Academic Press.
Record Number:CaltechAUTHORS:20151229-150907968
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Official Citation:Nagesh K. Mahanthappa, Fred H. Gage, Paul H. Patterson, Chapter 4 Adrenal chromaffin cells as multipotential neurons for autografts, In: S.B. Dunnett and S.-J. Richards, Editor(s), Progress in Brain Research, Elsevier, 1990, Volume 82, Pages 33-39, ISSN 0079-6123, ISBN 9780444811370, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63252
Deposited By: George Porter
Deposited On:10 Feb 2016 16:06
Last Modified:10 Nov 2021 23:14

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