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Autism: Neuropathology, Alterations of the GABAergic System, and Animal Models

van Kooten, Imke A. J. and Hof, Patrick R. and van Engeland, Herman and Steinbusch, Harry W. M. and Patterson, Paul H. and Schmitz, Christoph (2005) Autism: Neuropathology, Alterations of the GABAergic System, and Animal Models. In: GABA in Autism and Related Disorders. International Review of Neurobiology. No.71. Elsevier , New York, NY, pp. 1-26. ISBN 978-0-12-366872-1.

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This chapter discusses autism neuropathology, the role of GABAergic system, the system in which neurons produce gamma-aminobutyric acid (GABA) as their output, in this disorder, and the relevance of rodent models with autistic features. With respect to the neuropathology of autism, consistent findings have emerged for the limbic system, cerebellum, and cerebral cortex. The neuropathologic data of the limbic system show increased cell packing density and smaller neurons. These observations might be explained by an arrest of normal development. As with the cholinergic system, several studies have reported a reduction in GABA function, availability, and activity in autism. A decrease in GABA receptor binding has also been shown in autism. Evidence indicates that GABA plays a role in several developmental processes, including cell migration, proliferation, and differentiation. Although the neuropathologic results in autistic subjects are revealing, animal models are essential for a better understanding of the pathophysiology, cause, and treatment of autism. The recent linkages of neuroligin (NLGN), DLX, and engrailed 2 (En2) to autism offer possibilities for animal models, particularly if introducing the relevant, specific mutations (as opposed to simple knockouts [Kos]) and can cause interesting pathology and behavior.

Item Type:Book Section
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Additional Information:© 2005 Elsevier.
Series Name:International Review of Neurobiology
Issue or Number:71
Record Number:CaltechAUTHORS:20151229-234715148
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Official Citation:Imke A.J. van Kooten, Patrick R. Hof, Herman van Engeland, Harry W.M. Steinbusch, Paul H. Patterson, Christoph Schmitz, Autism: Neuropathology, Alterations of the GABAergic System, and Animal Models, International Review of Neurobiology, Academic Press, 2005, Volume 71, Pages 1-26, ISSN 0074-7742, ISBN 9780123668721, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63265
Deposited By: George Porter
Deposited On:08 Feb 2016 22:24
Last Modified:10 Nov 2021 23:14

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