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Nuclear magnetic resonance microscopy with 4-μm resolution: Theoretical study and experimental results

Cho, Z. H. and Ahn, C. B. and Juh, S. C. and Lee, H. K. and Jacobs, R. E. and Lee, S. and Yi, J. H. and Jo, J. M. (1988) Nuclear magnetic resonance microscopy with 4-μm resolution: Theoretical study and experimental results. Medical Physics, 15 (6). pp. 815-824. ISSN 0094-2405. https://resolver.caltech.edu/CaltechAUTHORS:20151230-152202126

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Abstract

Nuclear magnetic resonance(NMR) microscopy with 4‐μm resolution, a step closer to the 1‐μm resolution with which in vivo cellular imaging would be possible is described. An analysis of the ultimate resolution and voxel size dependent signal‐to‐noise ratio (SNR) in NMR microscopy is presented and experimentally verified. For microscopic scale objects (<1‐mm diameter), the SNR based on the geometrical scale factor (s) is found to be proportional to s n where n<2, rather than n=3 as previously supposed. This comes about because of a drastic reduction in sample noise coupled with a significant sensitivity gain realized in small diameter radio-frequency coils. A new pulse sequence which reduces both diffusion dependent resolution degradation and signal attenuation is presented. The selection of optimal bandwidth and acquisition time for maximal SNR is discussed. Experimental results obtained on both a 2.0‐T whole‐body system and a 7.0‐T small bore system adapted for microscopy indicate the potentials of 4‐μm resolution microscopy with the existing magnets.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1118/1.596287DOIArticle
http://scitation.aip.org/content/aapm/journal/medphys/15/6/10.1118/1.596287PublisherArticle
ORCID:
AuthorORCID
Jacobs, R. E.0000-0002-1382-8486
Additional Information:© 1988 American Association of Physicists in Medicine. Received 24 February 1988. Accepted 20 June 1988.
Issue or Number:6
Record Number:CaltechAUTHORS:20151230-152202126
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151230-152202126
Official Citation:Nuclear magnetic resonance microscopy with 4‐μm resolution: Theoretical study and experimental results Cho, Z. H. and Ahn, C. B. and Juh, S. C. and Lee, H. K. and Jacobs, R. E. and Lee, S. and Yi, J. H. and Jo, J. M., Medical Physics, 15, 815-824 (1988), DOI:http://dx.doi.org/10.1118/1.596287
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63271
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:08 Feb 2016 21:24
Last Modified:03 Oct 2019 09:26

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