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Towards a microMRI atlas of mouse development

Jacobs, R. E. and Ahrens, E. T. and Dickinson, M. E. and Laidlaw, D. (1999) Towards a microMRI atlas of mouse development. Computerized Medical Imaging and Graphics, 23 (1). pp. 15-24. ISSN 0895-6111. doi:10.1016/S0895-6111(98)00059-7.

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This study investigates the potential of microscopic Magnetic Resonance Imaging to obtain information for 3D digital atlases of mouse development using fixed samples. Fixed samples allow direct comparison with already published atlases and provide a testing ground for future in vivo efforts. 3D MR images of mouse embryos (dpc 6.5-16) illustrate that the necessary contrast and level of detail is available with this technique. Diffusion weighted imaging, diffusion tensor imaging, and multi-valued data sets are presented as examples of uniquely MR methods of obtaining anatomical information. MRI is performed non-invasively on the intact sample, leaving open the possibility of other manipulations (e.g. classical histology, immunohistochemistry, in situ hybridization, and in vitro growth for unfixed samples) after conducting the MRI experiment.

Item Type:Article
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Jacobs, R. E.0000-0002-1382-8486
Additional Information:© 1999 Elsevier.
Subject Keywords:MRI; Atlas; Mouse embryo; Morphogenesis; Multi-valued imaging; Development; Diffusion
Issue or Number:1
Record Number:CaltechAUTHORS:20151230-154521455
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Official Citation:R.E. Jacobs, E.T. Ahrens, M.E. Dickinson, D. Laidlaw, Towards a microMRI atlas of mouse development, Computerized Medical Imaging and Graphics, Volume 23, Issue 1, January–February 1999, Pages 15-24, ISSN 0895-6111, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63274
Deposited By: George Porter
Deposited On:08 Feb 2016 21:50
Last Modified:10 Nov 2021 23:14

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