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Competitive and positional cues in the patterning of nerve connections

Fraser, Scott E. and Perkel, Donald H. (1990) Competitive and positional cues in the patterning of nerve connections. Journal of Neurobiology, 21 (1). pp. 51-72. ISSN 0022-3034. https://resolver.caltech.edu/CaltechAUTHORS:20151230-235514454

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Abstract

The visual system of lower vertebrates has served as an important testing ground for the mechanisms that generate topographic neuronal connections. During both the outgrowth and the regeneration of the optic nerve, a smoothly ordered map of the retina is formed on its major target, the optic tectum (the retinotectal projection). Experiments performed on this projection have offered support for a variety of mechanisms, including the matching of positional cues in the retina and tectum, the guidance of nerve fibers by interactions between fibers, competition for synaptic space, and the refinement of connections based on neuronal activity. Unfortunately, individual experiments that support any one of these mechanisms have been taken at times as evidence against the involvement of any other mechanism; for example, experiments demonstrating the importance of positional cues have been thought mistakenly to indicate that activity-based interactions are unimportant. Computer simulations, in which multiple, somewhat opposed, mechanisms are allowed to operate in concert demonstrate that such a hybrid model is able to generate a full range of experimental results. More importantly, the elimination of any one of the mechanisms renders the model unable to fit entire classes of findings. Thus, the patterning of the retinotectal projection is best viewed as a process in which the optic nerve terminals attempt to satisfy multiple constraints in selecting their target sites.


Item Type:Article
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URLURL TypeDescription
http://dx.doi.org/10.1002/neu.480210105DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/neu.480210105/abstractPublisherArticle
ORCID:
AuthorORCID
Fraser, Scott E.0000-0002-5377-0223
Additional Information:© 1990 John Wiley & Sons. Received July 14, 1989; accepted September 12, 1989. We thank our colleagues at the University of California, Irvine and elsewhere for the many stimulating discussions that helped to shape this work. In particular, we thank Seth Tucker who participated actively in refining the implementation of the computer model and performed some of the simulations. Discussions with Dr. B. Oster and Dr. G. Oster were very helpful in formulating the version of the equations used here; a future publication will present an analytical treatment of the model performed wiuth Dr.s. Ermentrout and Oster. The modeling was supported by a grant form the NIH and a McKnight Foundation Scholar Award.
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Issue or Number:1
Record Number:CaltechAUTHORS:20151230-235514454
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151230-235514454
Official Citation:Fraser, S. E. and Perkel, D. H. (1990), Competitive and positional cues in the patterning of nerve connections. J. Neurobiol., 21: 51–72. doi: 10.1002/neu.480210105
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63279
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:27 Jan 2016 23:55
Last Modified:03 Oct 2019 09:27

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