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The neural crest: what can it tell us about cell migration and determination?

Bronner-Fraser, Marianne E. and Cohen, Alan M. (1980) The neural crest: what can it tell us about cell migration and determination? In: Neural Development Part I: Emergence of Specificity in Neural Histogenesis. Current Topics in Developmental Biology. No.15. Academic Press , New York, NY, pp. 1-25. ISBN 0-12-153115-5. https://resolver.caltech.edu/CaltechAUTHORS:20160101-141827472

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Abstract

Of all vertebrate structures, the nervous system has perhaps the greatest cellular diversification and complexity of organization. The study of developmental neurobiology, therefore, sharply probes the central issue of embryogenesis; i.e., how does a complex system arise form a single cell? During development, ectodermal tissue becomes determined along neuronal lines via contact or "primary induction" from the roof of the archenteron (Mangold, 1933; Spemann, 1938). A major problem is how the morphologically indistinguishable stem cells of the neuroectoderm become progressively determined along divergent developmental lines such that they give rise to a myriad of cell types in the mature nervous system. Another question posed by this system is how the cells migrate to their final locations and become organized in precise spatial arrays. Once the pattern is composed, what mechanisms govern the establishment of the proper connections between neurons and other neurons, as well as between neurons and their target organs?


Item Type:Book Section
ORCID:
AuthorORCID
Bronner-Fraser, Marianne E.0000-0003-4274-1862
Additional Information:© 1980 Academic Press. We express our gratitude to Ms. Susan Jaffe for her expert technical assistance. The research was supported by U.S. Public Health Service Grant HD-07389 and A Basic Research Grant from the National Foundation-March of Dimes.
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)HD-07389
National Foundation - March of DimesUNSPECIFIED
Series Name:Current Topics in Developmental Biology
Issue or Number:15
Record Number:CaltechAUTHORS:20160101-141827472
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160101-141827472
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63285
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:04 Feb 2016 16:31
Last Modified:03 Oct 2019 09:27

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