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Analysis of neural crest cell lineage and migration

Bronner-Fraser, M. and Stern, C. D. and Fraser, S. (1991) Analysis of neural crest cell lineage and migration. Journal of craniofacial genetics and developmental biology, 11 (4). pp. 214-22. ISSN 0270-4145.

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In this review, we describe the results of recent experiments designed to investigate various aspects of neural crest cell lineage and migration. We have analyzed the lineage of individual premigratory neural crest cells by injecting a fluorescent lineage tracer dye, lysinated fluorescein dextran, into cells within the dorsal neural tube. Individual clones contained cells that were located in very diverse sites consistent with their being sensory neurons, prepigment cells, Schwann cells, adrenergic cells, and neural tube cells. These results suggest that some neural crest cells in the trunk and cranial regions are multipotent prior to their emigration from the neural tube. The environment through which neural crest cells move influences both the pattern and direction of their migration. We have shown that the sclerotomal portion of the somites are responsible for the rostrocaudal pattern of trunk neural crest cell movement, whereas the neural tube appears to govern the dorsoventral position of neural crest-derived ganglia. In addition, the notochord inhibits the movement of neural crest cells. In order to understand necessary cell-matrix interactions in neural crest migration, we have performed perturbation experiments, in which antibodies directed against cell surface or extracellular matrix molecules were introduced along neural crest pathways. We find that integrins, fibronectin, laminin, and tenascin all play some role in cranial neural crest emigration. Thus, multiple factors may be involved in controlling neural crest cell migration, and different factors may be important for migration in different regions of the embryo.

Item Type:Article
Bronner-Fraser, M.0000-0003-4274-1862
Fraser, S.0000-0002-5377-0223
Additional Information:© 1991 Wiley-Liss.
Issue or Number:4
Record Number:CaltechAUTHORS:20160101-180403287
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63292
Deposited By: George Porter
Deposited On:26 Jan 2016 20:55
Last Modified:03 Oct 2019 09:27

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