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Inductive interactions underlie neural crest formation

Bronner-Fraser, Marianne (1997) Inductive interactions underlie neural crest formation. In: Catacholamines: bridging basic science with clinical medicine. Advances in Pharmacology. No.42. Academic Press , San Diego, CA, pp. 883-887. ISBN 978-0-12-032943-4. https://resolver.caltech.edu/CaltechAUTHORS:20160101-190432495

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Abstract

The neural crest is a transient population of cells defined in terms of their ectodermal origin, their migratory behavior, and their derivatives. Neural crest cells classically have been thought to be a segregated population within the neural plate, bordered laterally by presumptive epidermis and medially by prospective central nervous system (CNS). Cell lineage analyses in vitro and in vivo have demonstrated that individual neural crest cells are multipotent. In fact, they have the properties of stem cells with at least a limited ability to self-renew. The experiments summarized in this chapter demonstrate that interactions between the presumptive neural plate and the nonneural ectoderm lead to induction of the avian neural crest at the interface between these tissues. This supports the idea that an inductive signal travels through the epidermis to generate neural crest cells in the gastrulating embryo. On the other hand, the competence of the neural plate to form different types of neural crest derivatives appears to change with time. BMP4 and BMP7 (bone morphogenetic proteins) have been shown to be sufficient to substitute for the nonneural ectoderm in inducing neural crest cells. The neural tube has a characteristic polarity along the rostrocaudal and the dorsoventral axes. Rostrocaudal regionalization is manifested by the formation of subdivisions in the neural tube, such as the forebrain, midbrain, hindbrain, and spinal cord. Neural crest cells arising from different axial levels contribute to derivatives characteristic of the axial level of origin. It has been demonstrated that dorsalizing signals influence development of not only the neural crest, but also the dorsal neural tube. Various genes are selectively expressed in the dorsal, but not in the ventral, portion of the neural tube.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S1054-3589(08)60888-1DOIArticle
http://www.sciencedirect.com/science/article/pii/S1054358908608881PublisherArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 1998 Academic Press.
Series Name:Advances in Pharmacology
Issue or Number:42
Record Number:CaltechAUTHORS:20160101-190432495
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160101-190432495
Official Citation:Marianne Bronner-Fraser, Inductive Interactions Underlie Neural Crest Formation, In: David S. Goldstein, Graeme Eisenhofer and Richard McCarty, Editor(s), Advances in Pharmacology, Academic Press, 1997, Volume 42, Pages 883-887, ISSN 1054-3589, ISBN 9780120329434, http://dx.doi.org/10.1016/S1054-3589(08)60888-1. (http://www.sciencedirect.com/science/article/pii/S1054358908608881)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63298
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:22 Jan 2016 22:45
Last Modified:03 Oct 2019 09:27

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