Hierarchy of events regulating neural crest induction

Abstract

The neural crest is a group of cells that has a transient existence in the developing vertebrate embryo. Arising at the edges of the neural plate during nervous a formation, these cells initiate life within the central nervous system but soon leave to invade the far reaches of the body (Fig. 7.1). They undergo an epithelial to mesenchymal transition, emigrate from the neuroepithelium, and become a highly migratory cell type that follows distinct and characteristic pathways to numerous sites. They populate most of the peripheral nervous system, parts of the adrenal gland, and much of the facial region. Upon reaching their final destinations, these cells differentiate into a myriad of cell types ranging from pigment cells to sensory and autonomic neurons to cartilage and bone of the face.