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Gene Regulatory Network Analysis in Sea Urchin Embryos

Oliveri, Paola and Davidson, Eric H. (2004) Gene Regulatory Network Analysis in Sea Urchin Embryos. In: Development of Sea Urchins, Ascidians, and Other Invertebrate Deuterostomes: Experimental Approaches. Methods in Cell Biology. No.74. Elsevier , Amsterdam, pp. 775-794. ISBN 9780124802780. https://resolver.caltech.edu/CaltechAUTHORS:20160106-141008422

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Abstract

This chapter considers special methodologies developed for gene regulatory network (GRN) analysis and for the use of GRNs. The GRNs provide logic maps of the control functions that direct development, and they relate these maps directly to the genomic regulatory sequence. A GRN indicates what inputs into each regulatory gene are responsible for its spatial and temporal patterns of expression. It thereby explains the progression of regulatory states that underlies spatial specification of domain fate in development and thereafter the institution of regional cell differentiation. The chapter examines how intercellular signaling and developmentally important maternal anisotropies are linked into the gene regulatory apparatus of the embryonic cells—that is, why signaling interactions and localizations in the egg affect the developmental process. A properly constructed GRN has an immense predictive, as well as explanatory potentiality. The sea urchin embryo has turned out to be a material of choice for the system-level, high-throughput kinds of research required for GRN analysis. A large-scale provisional GRN for embryonic endomesoderm specification has been worked out for sea urchin (Strongylocentrotus purpuratus) embryos.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0091-679X(04)74032-7DOIArticle
http://www.sciencedirect.com/science/article/pii/S0091679X04740327PublisherArticle
Additional Information:© 2004 Elsevier Inc. P. O. was supported by the Camilla Chandler Frost Fellowship. Research was supported by NIH grant HD37105, by the Office of Science (BER), U. S. Department of Energy, grant DE-FG02-03ER63584, and by the Caltech Beckman Institute.
Funders:
Funding AgencyGrant Number
Camilla Chandler Frost FellowshipUNSPECIFIED
NIHHD37105
Department of Energy (DOE)DE-FG02-03ER63584
Caltech Beckman InstituteUNSPECIFIED
Series Name:Methods in Cell Biology
Issue or Number:74
Record Number:CaltechAUTHORS:20160106-141008422
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160106-141008422
Official Citation:Paola Oliveri, Eric H. Davidson, Gene Regulatory Network Analysis in Sea Urchin Embryos, Methods in Cell Biology, Academic Press, 2004, Volume 74, Pages 775-794, ISSN 0091-679X, ISBN 9780124802780, http://dx.doi.org/10.1016/S0091-679X(04)74032-7. (http://www.sciencedirect.com/science/article/pii/S0091679X04740327)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63430
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Jan 2016 22:47
Last Modified:03 Oct 2019 09:28

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