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Conversion of Amides into Esters by the Nickel-Catalyzed Activation of Amide C-N Bonds

Garg, Neil and Houk, Kendall N. and Baker, Emma L. and Nathel, Noah F. Fine and Hie, Liana and Hong, Xin and Liu, Peng and Shah, Tejas K. and Yang, Yun-fang (2016) Conversion of Amides into Esters by the Nickel-Catalyzed Activation of Amide C-N Bonds. Synlett, 27 (1). A3-A8. ISSN 0936-5214. doi:10.1055/s-0035-1560598.

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The amide function is ubiquitous in natural compounds as well as in man-made molecules and materials. It is generally very stable and poorly reactive owing to its resonance-stabilized C–N group that imparts a planar geometry to amides. In contrast, carboxylic esters are generally reactive under a variety of mild conditions; therefore, it is not surprising that a number of direct methods are available to the chemist for converting esters into amides (amino-de-alkoxylation reaction) but very few for achieving the opposite transformation. Recently, Professors Neil Garg and Ken Houk from the University of California, Los Angeles (UCLA, USA) reported in Nature a groundbreaking method for converting amides into esters with a high degree of efficiency.

Item Type:Article
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URLURL TypeDescription
Houk, Kendall N.0000-0002-8387-5261
Hong, Xin0000-0003-4717-2814
Liu, Peng0000-0002-8188-632X
Yang, Yun-fang0000-0002-6287-1640
Additional Information:© 2016 Georg Thieme Verlag.
Issue or Number:1
Record Number:CaltechAUTHORS:20160119-082839289
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63747
Deposited By: Tony Diaz
Deposited On:21 Jan 2016 00:56
Last Modified:10 Nov 2021 23:20

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