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Disruption of Segmental Neural Crest Migration and Ephrin Expression in Delta-1 Null Mice

De Bellard, Maria Elena and Ching, Wendy and Gossler, Achim and Bronner-Fraser, Marianne (2002) Disruption of Segmental Neural Crest Migration and Ephrin Expression in Delta-1 Null Mice. Developmental Biology, 249 (1). pp. 121-130. ISSN 0012-1606. https://resolver.caltech.edu/CaltechAUTHORS:20160121-071017262

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Abstract

Neural crest cells migrate segmentally through the rostral half of each trunk somite due to inhibitory influences of ephrins and other molecules present in the caudal-half of somites. To examine the potential role of Notch/Delta signaling in establishing the segmental distribution of ephrins, we examined neural crest migration and ephrin expression in Delta-1 mutant mice. Using Sox-10 as a marker, we noted that neural crest cells moved through both rostral and caudal halves of the somites in mutants, consistent with the finding that ephrinB2 levels are significantly reduced in the caudal-half somites. Later, mutant embryos had aberrantly fused and/or reduced dorsal root and sympathetic ganglia, with a marked diminution in peripheral glia. These results show that Delta-1 is essential for proper migration and differentiation of neural crest cells. Interestingly, absence of Delta-1 leads to diminution of both neurons and glia in peripheral ganglia, suggesting a general depletion of the ganglion precursor pool in mutant mice.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1006/dbio.2002.0756DOIArticle
http://www.sciencedirect.com/science/article/pii/S0012160602907566PublisherArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2002 Elsevier Science. Received for publication April 11, 2002. Revised May 17, 2002. Accepted May 21, 2002. Published online July 31, 2002. We thank Gustavo Gomez for excellent technical assistance. This work was supported by USPHS, HD-15527 NS-41070 and Human Frontiers Grant RG0146 (to M.B.-F.) with a minority supplement to MEdB on HD-15527. We thank Dr. David J. Anderson (Caltech) for Sox10, ephrin and Eph cDNA probes, and Dr. Rusty Lansford (Caltech) for ephrinB1- and ephrinA5-Fc.
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)HD-15527
U.S. Public Health Service (USPHS)NS-41070
Human Frontier Science ProgramRG0146
Issue or Number:1
Record Number:CaltechAUTHORS:20160121-071017262
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160121-071017262
Official Citation:Maria Elena De Bellard, Wendy Ching, Achim Gossler, Marianne Bronner-Fraser, Disruption of Segmental Neural Crest Migration and Ephrin Expression in Delta-1 Null Mice, Developmental Biology, Volume 249, Issue 1, 1 September 2002, Pages 121-130, ISSN 0012-1606, http://dx.doi.org/10.1006/dbio.2002.0756. (http://www.sciencedirect.com/science/article/pii/S0012160602907566)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63816
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:21 Jan 2016 19:12
Last Modified:03 Oct 2019 09:31

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