A Caltech Library Service

Corneal keratocytes retain neural crest progenitor cell properties

Lwigale, Peter Y. and Cressy, Paola A. and Bronner-Fraser, Marianne (2005) Corneal keratocytes retain neural crest progenitor cell properties. Developmental Biology, 288 (1). pp. 284-293. ISSN 0012-1606. doi:10.1016/j.ydbio.2005.09.046.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Corneal keratocytes have a remarkable ability to heal the cornea throughout life. Given their developmental origin from the cranial neural crest, we asked whether this regenerative ability was related to the stem cell-like properties of their neural crest precursors. To this end, we challenged corneal stromal keratocytes by injecting them into a new environment along cranial neural crest migratory pathways. The results show that injected stromal keratocytes change their phenotype, proliferate and migrate ventrally adjacent to host neural crest cells. They then contribute to the corneal endothelial and stromal layers, the musculature of the eye, mandibular process, blood vessels and cardiac cushion tissue of the host. However, they fail to form neurons in cranial ganglia or branchial arch cartilage, illustrating that they are at least partially restricted progenitors rather than stem cells. The data show that, even at late embryonic stages, corneal keratocytes are not terminally differentiated, but maintain plasticity and multipotentiality, contributing to non-neuronal cranial neural crest derivatives.

Item Type:Article
Related URLs:
URLURL TypeDescription
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2005 Elsevier Inc. Received for publication 19 August 2005, revised 27 September 2005, accepted 30 September 2005. Available online 2 November 2005. We are grateful to Dr. James Funderburgh for providing the I22 antibody and to Anitha Rao for technical assistance. This work was supported by an Elizabeth Ross Fellowship (to PYL), and NIH grant, NS 36585 (to MBF).
Funding AgencyGrant Number
Elizabeth Ross FellowshipUNSPECIFIED
NIHNS 36585
Subject Keywords:Cornea; Neural crest; Keratocyte; Differentiation
Issue or Number:1
Record Number:CaltechAUTHORS:20160121-135400792
Persistent URL:
Official Citation:Peter Y. Lwigale, Paola A. Cressy, Marianne Bronner-Fraser, Corneal keratocytes retain neural crest progenitor cell properties, Developmental Biology, Volume 288, Issue 1, 1 December 2005, Pages 284-293, ISSN 0012-1606, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63847
Deposited By: Ruth Sustaita
Deposited On:22 Jan 2016 21:02
Last Modified:10 Nov 2021 23:22

Repository Staff Only: item control page