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Ancient Evolutionary Origin of the Neural Crest Gene Regulatory Network

Sauka-Spengler, Tatjana and Meulemans, Daniel and Jones, Matthew and Bronner-Fraser, Marianne (2007) Ancient Evolutionary Origin of the Neural Crest Gene Regulatory Network. Developmental Cell, 13 (3). pp. 405-420. ISSN 1534-5807. doi:10.1016/j.devcel.2007.08.005. https://resolver.caltech.edu/CaltechAUTHORS:20160122-105354645

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Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20160122-105354645

Abstract

The vertebrate neural crest migrates from its origin, the neural plate border, to form diverse derivatives. We previously hypothesized that a neural crest gene regulatory network (NC-GRN) guides neural crest formation. Here, we investigate when during evolution this hypothetical network emerged by analyzing neural crest formation in lamprey, a basal extant vertebrate. We identify 50 NC-GRN homologs and use morpholinos to demonstrate a critical role for eight transcriptional regulators. The results reveal conservation in deployment of upstream factors, suggesting that proximal portions of the network arose early in vertebrate evolution and have been conserved for >500 million years. We found biphasic expression of neural crest specifiers and differences in deployment of some specifiers and effectors expected to confer species-specific properties. By testing the collective expression and function of neural crest genes in a single, basal vertebrate, we reveal the ground state of the NC-GRN and resolve ambiguities between model organisms.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.devcel.2007.08.005DOIArticle
http://www.cell.com/developmental-cell/abstract/S1534-5807%2807%2900305-XPublisherArticle
ORCID:
AuthorORCID
Sauka-Spengler, Tatjana0000-0001-9289-0263
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2007 Elsevier Inc. Received: December 14, 2006. Revised: March 9, 2007. Accepted: August 15, 2007. Published: September 4, 2007. We thank Dr. J. Langeland for providing material and expertise during cDNA library construction; C. Krontiris and P. Fraser for excellent assistance; Drs. S. Fraser and N. Nikitina for critical reading of the manuscript; Dr. Y. Kee for sharing reagents and expertise; Drs. S. Bhattacharyya and M. Barembaum for helpful discussions; Drs. A. Monsoro-Burq and J.-P. Saint-Jeannet for providing Xenopus Msx1 and Zic1 clones; R. Bergstedt and the staff at Hammond Bay Biological Station for kindly providing animals; and N. Johnson for sending spawning adult lampreys. This work was supported by DE17911 to M.B.F.
Funders:
Funding AgencyGrant Number
NIHDE17911
Issue or Number:3
DOI:10.1016/j.devcel.2007.08.005
Record Number:CaltechAUTHORS:20160122-105354645
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160122-105354645
Official Citation:Ancient Evolutionary Origin of the Neural Crest Gene Regulatory Network Sauka-Spengler, Tatjana et al. Developmental Cell , Volume 13 , Issue 3 , 405 - 420
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63889
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:22 Jan 2016 20:42
Last Modified:10 Nov 2021 23:22

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