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Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus

Shi, Limin and Tu, Nora and Patterson, Paul H. (2005) Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus. International Journal of Developmental Neuroscience, 23 (2-3). pp. 299-305. ISSN 0736-5748. https://resolver.caltech.edu/CaltechAUTHORS:20160122-105358033

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Abstract

Epidemiological studies have shown that maternal infection can increase the risk for mental illness in the offspring. In a mouse model of maternal respiratory infection with influenza virus, the adult offspring display striking behavioral, pharmacological and histological abnormalities. Although influenza primarily infects the respiratory system, there are reports of viral mRNA and protein in the fetus of infected pregnant animals. To determine the extent of viral spread following maternal respiratory infection, we used RT–PCR to assay various maternal and fetal tissues for influenza A mRNAs coding for neuraminidase, non-structural protein 2, nuclear protein and matrix protein. While infected maternal lungs exhibit uniformly very strong signals, placentae are only rarely positive, and viral RNAs are not detectable in fetal brains from infected mothers. Thus, the effects of maternal infection on fetal brain development are likely to be indirect, probably involving the maternal inflammatory response.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.ijdevneu.2004.05.005DOIArticle
http://www.sciencedirect.com/science/article/pii/S0736574804000607PublisherArticle
Additional Information:© 2004 ISDN. Published by Elsevier Ltd. Received 24 April 2004; received in revised form 18 May 2004; accepted 19 May 2004. We thank D. McDowell for administrative assistance, and B. Deverman, N. Malkova, A. Khoshnan and S. Smith for comments on the manuscript. B. Deverman and M.-J. Fann also provided valuable advice on the design of PCR primers. Financial support was provided by Ginger and Ted Jenkins, the Stanley Medical Research Institute, the McKnight Foundation and the National Institute of Mental Health. N. Tu was partially supported by a Caltech Summer Undergraduate Research Fellowship.
Funders:
Funding AgencyGrant Number
Ginger and Ted JenkinsUNSPECIFIED
Stanley Medical Research InstituteUNSPECIFIED
McKnight FoundationUNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
Caltech Summer Undergraduate Research Fellowship (SURF)UNSPECIFIED
Subject Keywords:Influenza; Brain development; Fetus
Issue or Number:2-3
Record Number:CaltechAUTHORS:20160122-105358033
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160122-105358033
Official Citation:Limin Shi, Nora Tu, Paul H. Patterson, Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus, International Journal of Developmental Neuroscience, Volume 23, Issues 2–3, April–May 2005, Pages 299-305, ISSN 0736-5748, http://dx.doi.org/10.1016/j.ijdevneu.2004.05.005. (http://www.sciencedirect.com/science/article/pii/S0736574804000607)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63897
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:25 Jan 2016 19:27
Last Modified:03 Oct 2019 09:32

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