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The role of cytokines and growth factors in seizures and their sequelae

Jankowsky, Joanna L. and Patterson, Paul H. (2001) The role of cytokines and growth factors in seizures and their sequelae. Progress in Neurobiology, 63 (2). pp. 125-149. ISSN 0301-0082.

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Although the neuropathological changes caused by severe or repeated seizures have been well characterized, many questions about the molecular mechanisms involved remain unanswered. Neuronal cell death, reactive gliosis, enhanced neurogenesis, and axonal sprouting are four of the best-studied sequelae of seizures. In vitro, each of these pathological processes can be substantially influenced by soluble protein factors, including neurotrophins, cytokines, and growth factors. Furthermore, many of these proteins and their receptors are expressed in the adult brain and are up-regulated in response to neuronal activity and injury. We review the evidence that these intercellular signaling proteins regulate seizure activity as well as subsequent pathology in vivo. As nerve growth factor and brain derived neurotrophic factor are the best-studied proteins of this class, we begin by discussing the evidence linking these neurotrophins to epilepsy and seizure. More than a dozen additional cytokines, growth factors, and neurotrophins that have been examined in the context of epilepsy models are then considered. We discuss the effect of seizure on expression of cytokines and growth factors, and explore the regulation of seizure development and aftermath by exogenous application or antagonist perturbation of these proteins. The experimental evidence supports a role for these factors in each aspect of seizure and pathology, and suggests potential targets for future therapeutics.

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Additional Information:© 2000 Elsevier Science Ltd. Available online 19 December 2000.
Subject Keywords:Cytokine; Growth factor; Neurotrophin; Interleukin; IL-6; NGF; Seizure; Kainate; Kindling; Electroconvulsive shock; Epilepsy
Issue or Number:2
Record Number:CaltechAUTHORS:20160122-105358289
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Official Citation:Joanna L. Jankowsky, Paul H. Patterson, The role of cytokines and growth factors in seizures and their sequelae, Progress in Neurobiology, Volume 63, Issue 2, February 2001, Pages 125-149, ISSN 0301-0082, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63898
Deposited By: Ruth Sustaita
Deposited On:22 Jan 2016 20:24
Last Modified:03 Oct 2019 09:32

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