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DNA-Mediated Electron Transfer: A Sensitive Probe of DNA-Protein Interactions

Rajski, Scott R. and Barton, Jacqueline K. (2000) DNA-Mediated Electron Transfer: A Sensitive Probe of DNA-Protein Interactions. Journal of Biomolecular Structure and Dynamics , 17 (S1). pp. 285-291. ISSN 0739-1102. http://resolver.caltech.edu/CaltechAUTHORS:20160125-195950967

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Abstract

The ability of the π-stacked array of heterocyclic DNA bases to behave as an efficient conduit for charge migration has been explored using a wide array of experimental approaches. Spectroscopic studies and biochemical assays show that charge transfer through well-stacked DNA can be extremely facile, although sensitive to structural distortions within the DNA base stack. The efficiency of these long-range reactions depends upon the coupling of the electron donor, acceptor and intervening base pairs within the base stack. As a result, base mismatches and stacking disruptions associated with protein binding to the helix can significantly perturb long range charge transfer. DNA-protein interactions which result in the base flipping of a nucleotide out of the DNA π-stack, in particular, dramatically inhibit long-range charge transfer through DNA. Whether these reactions that can occur over large molecular distances, be applied in sensing DNA damage, and be modulated by DNA-binding proteins, are exploited within the cell remains to be determined.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1080/07391102.2000.10506633DOIArticle
http://www.tandfonline.com/doi/abs/10.1080/07391102.2000.10506633PublisherArticle
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2000 Adenine Press. Special Issue: Proceedings of the Eleventh Conversation.
Record Number:CaltechAUTHORS:20160125-195950967
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160125-195950967
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63954
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:27 Jan 2016 21:15
Last Modified:27 Jan 2016 21:15

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