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DNA-Mediated Electron Transfer: A Sensitive Probe of DNA-Protein Interactions

Rajski, Scott R. and Barton, Jacqueline K. (2000) DNA-Mediated Electron Transfer: A Sensitive Probe of DNA-Protein Interactions. Journal of Biomolecular Structure and Dynamics, 17 (S1). pp. 285-291. ISSN 0739-1102. doi:10.1080/07391102.2000.10506633.

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The ability of the π-stacked array of heterocyclic DNA bases to behave as an efficient conduit for charge migration has been explored using a wide array of experimental approaches. Spectroscopic studies and biochemical assays show that charge transfer through well-stacked DNA can be extremely facile, although sensitive to structural distortions within the DNA base stack. The efficiency of these long-range reactions depends upon the coupling of the electron donor, acceptor and intervening base pairs within the base stack. As a result, base mismatches and stacking disruptions associated with protein binding to the helix can significantly perturb long range charge transfer. DNA-protein interactions which result in the base flipping of a nucleotide out of the DNA π-stack, in particular, dramatically inhibit long-range charge transfer through DNA. Whether these reactions that can occur over large molecular distances, be applied in sensing DNA damage, and be modulated by DNA-binding proteins, are exploited within the cell remains to be determined.

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Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2000 Adenine Press. Special Issue: Proceedings of the Eleventh Conversation.
Issue or Number:S1
Record Number:CaltechAUTHORS:20160125-195950967
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63954
Deposited By: George Porter
Deposited On:27 Jan 2016 21:15
Last Modified:10 Nov 2021 23:23

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