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Radical migration through the DNA helix: chemistry at a distance

Kelley, Shana O. and Barton, Jacqueline K. (1999) Radical migration through the DNA helix: chemistry at a distance. In: Interrelations Between Free Radicals and Metal Ions in Life Processes. Metal Ions in Biological Systems. No.36. Marcel Dekker , New York, NY, pp. 211-249. ISBN 9780824719562.

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The reaction of the DNA bases with radical species generated by radiation, carcinogens, or oxidative stress can lead to mutagenic damage [1]. The efficiency and dynamics of radical transport through the DNA helix therefore hold profound biological implications. Intriguing questions concerning charge migration through DNA arise that can now begin to be addressed through well-defined chemical experiments. Does radical migration through DNA occur over long molecular distances? How is it modulated by DNA sequence and the structural variations in DNA? Is it physiologically important? How general is this phenomenon? These are issues that need to be addressed in the context of delineating mechanisms of DNA damage and repair.

Item Type:Book Section
Kelley, Shana O.0000-0003-3360-5359
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 1999 Marcel Dekker. We are grateful to the National Institutes of Health and the National Foundation for Cancer Research for their financial support of this work. In addition, we thank our colleagues and collaborators, as referenced throughout the chapter, for their efforts and their ideas.
Funding AgencyGrant Number
National Foundation for Cancer ResearchUNSPECIFIED
Series Name:Metal Ions in Biological Systems
Issue or Number:36
Record Number:CaltechAUTHORS:20160125-201652834
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63955
Deposited By: George Porter
Deposited On:08 Feb 2016 21:42
Last Modified:03 Oct 2019 09:33

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