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A crystalline platinum blue: its molecular structure, chemical reactivity, and possible relevance to the mode of action of antitumor platinum drugs

Barton, Jacqueline K. and Lippard, Stephen J. (1978) A crystalline platinum blue: its molecular structure, chemical reactivity, and possible relevance to the mode of action of antitumor platinum drugs. Annals of the New York Academy of Sciences, 313 . pp. 686-700. ISSN 0077-8923. https://resolver.caltech.edu/CaltechAUTHORS:20160126-164221837

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Abstract

The simple inorganic complex cis-dichlorodiammineplatinum (II) (DDP) inhibits the division of bacterial cells with little effect on their growth. It was subsequently shown that DDP has substantial antitumor activity on a wide variety of animal malignancies. These findings stimulated numerous investigations of diammineplatinum (II) complexes both to establish their mode of action and to design more effective antitumor platinum drugs.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/j.1749-6632.1978.tb39455.xDOIArticle
http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1978.tb39455.x/abstractPublisherArticle
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 1978 New York Academy of Sciences. Manuscript received July 11, 1977. Supported by National Institutes of Health Research Grant no. CA-15826 from the National Cancer Institute. J.K.B. is the recipient of a Predoctoral Fellowship from the National Science Foundation. We are grateful to Engelhard Industries for generous loans of K_2PtCl_4.
Funders:
Funding AgencyGrant Number
National Cancer InstituteCA-15826
NSF Predoctoral FellowshipUNSPECIFIED
Record Number:CaltechAUTHORS:20160126-164221837
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160126-164221837
Official Citation:Barton, J. K. and Lippard, S. J. (1978), A CRYSTALLINE PLATINUM BLUE: ITS MOLECULAR STRUCTURE, CHEMICAL REACTIVITY, AND POSSIBLE RELEVANCE TO THE MODE OF ACTION OF ANTITUMOR PLATINUM DRUGS. Annals of the New York Academy of Sciences, 313: 686–700. doi: 10.1111/j.1749-6632.1978.tb39455.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:63987
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:27 Jan 2016 19:05
Last Modified:03 Oct 2019 09:33

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