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Charge transport in DNA

Boon, Elizabeth M. and Barton, Jacqueline K. (2002) Charge transport in DNA. Current Opinion in Structural Biology, 12 (3). pp. 320-329. ISSN 0959-440X. doi:10.1016/S0959-440X(02)00327-5. https://resolver.caltech.edu/CaltechAUTHORS:20160127-111126226

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Abstract

The base pair stack within double helical DNA provides an effective medium for charge transport. The DNA π-stack mediates oxidative DNA damage over long molecular distances in a reaction that is exquisitely sensitive to the sequence-dependent conformation and dynamics of DNA. A mixture of tunneling and hopping mechanisms have been proposed to account for this long-range chemistry, which is gated by dynamical variations within the stack. Electrochemical sensors have also been developed, based upon the sensitivity of DNA charge transport to base pair stacking, and these sensors provide a completely new approach to diagnosing single base mismatches in DNA and monitoring protein–DNA interactions electrically. DNA charge transport, furthermore, may play a role within the cell and, indeed, oxidative damage to DNA from a distance has been demonstrated in the cell nucleus. As a result, the biological consequences of and opportunities for DNA-mediated charge transport now require consideration.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0959-440X(02)00327-5DOIArticle
http://www.sciencedirect.com/science/article/pii/S0959440X02003275PublisherArticle
ORCID:
AuthorORCID
Boon, Elizabeth M.0000-0003-1891-839X
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2002 Elsevier Science Ltd. Available online 17 July 2002.
Subject Keywords:DNA-mediated charge transport; guanine hopping; DNA structure; DNA dynamics; Oxidative damage; Mismatch/mutation detection; DNA chip; DNA-protein interaction; DNA damage; DNA repair
Issue or Number:3
DOI:10.1016/S0959-440X(02)00327-5
Record Number:CaltechAUTHORS:20160127-111126226
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160127-111126226
Official Citation:Elizabeth M Boon, Jacqueline K Barton, Charge transport in DNA, Current Opinion in Structural Biology, Volume 12, Issue 3, 1 June 2002, Pages 320-329, ISSN 0959-440X, http://dx.doi.org/10.1016/S0959-440X(02)00327-5. (http://www.sciencedirect.com/science/article/pii/S0959440X02003275)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64006
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:27 Jan 2016 19:50
Last Modified:10 Nov 2021 23:24

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