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Multiple Length DNA Molecules of Bacteriophage φX174

Benbow, R. M. and Eisenberg, M. and Sinsheimer, R. L. (1972) Multiple Length DNA Molecules of Bacteriophage φX174. Nature New Biology, 237 (74). pp. 141-144. ISSN 0369-4887. http://resolver.caltech.edu/CaltechAUTHORS:20160127-115432856

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Abstract

Rush and Warner have suggested that circular double length DNA molecules of bacteriophage S13 arise during genetic recombination, presumably in a single reciprocal recombination event between two monomeric circles. In other systems, however, circular molecules of multiple length are produced by errors in replication. We now demonstrate that most circular multiple length DNA molecules of bacteriophage φX174 arise by replication and that, moreover, some catenated DNA molecules contain interlocked rings of two different parental types.


Item Type:Article
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http://www.nature.com/nature-newbio/journal/v237/n74/pdf/newbio237141a0.pdfPublisherArticle
Additional Information:© 1972 Nature Publishing Group. Received December 6, 1971; revised February 14, 1972. We thank Drs Paul Howard-Flanders and Philip Sharp for suggestions and Mrs J. S. Kim for the plates in Fig. 2. This research was supported by a grant from the US Public Health Service. R. B. is supported by a National Institutes of Health training grant, and M. E. by a fellowship from the Rockefeller Foundation.
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Funding AgencyGrant Number
U.S. Public Health Service (USPHS)UNSPECIFIED
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Rockefeller FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20160127-115432856
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160127-115432856
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64015
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:27 Jan 2016 21:22
Last Modified:13 Feb 2019 18:06

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