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Logic of gene regulatory networks

Materna, Stefan C. and Davidson, Eric H. (2007) Logic of gene regulatory networks. Current Opinion in Biotechnology, 18 (4). pp. 351-354. ISSN 0958-1669. PMCID PMC2031216. doi:10.1016/j.copbio.2007.07.008.

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Regulatory networks of transcription factors and signaling molecules lie at the heart of development. Their architecture implements logic functions whose execution propels cells from one regulatory state to the next, thus driving development forward. As an example of a subcircuit that translates transcriptional input into developmental output, we consider a particularly simple case, the regulatory processes underlying pigment cell formation in sea urchin embryos. The regulatory events in this process can be represented as elementary logic functions.

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Additional Information:© 2007 Elsevier Ltd. Available online 6th August 2007. We would like to thank Andy Ransick, Jongmin Nam and Smadar Ben-Tabou de-Leon for helpful discussions. Research was supported by NIH grant HD-37105.
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Issue or Number:4
PubMed Central ID:PMC2031216
Record Number:CaltechAUTHORS:20160127-153937738
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Official Citation:Stefan C Materna, Eric H Davidson, Logic of gene regulatory networks, Current Opinion in Biotechnology, Volume 18, Issue 4, August 2007, Pages 351-354, ISSN 0958-1669, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64027
Deposited By: Ruth Sustaita
Deposited On:28 Jan 2016 22:59
Last Modified:10 Nov 2021 23:24

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