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Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness

Patterson, Paul H. (2002) Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness. Current Opinion in Neurobiology, 12 (1). pp. 115-118. ISSN 0959-4388. doi:10.1016/S0959-4388(02)00299-4. https://resolver.caltech.edu/CaltechAUTHORS:20160127-153938256

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Abstract

Direct viral infection of the developing brain can have disastrous consequences for the fetus. More subtle and perhaps more insidious are viral infections of the pregnant mother, which can have long-lasting effects such as an increased risk of schizophrenia in the offspring. A recent mouse model has shown that respiratory infection in the pregnant mother leads to marked behavioral and pharmacological abnormalities in the offspring, some of which are relevant for schizophrenia and autism. This effect on fetal brain development might be caused by the maternal antiviral immune response, possibly mediated by cytokines.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0959-4388(02)00299-4DOIArticle
http://www.sciencedirect.com/science/article/pii/S0959438802002994PublisherArticle
Additional Information:© 2002 Elsevier Science Ltd. Available online 16 February 2002. The work cited from the author’s laboratory is supported by Ginger and Ted Jenkins, the Mettler Autism Fund, and the Stanley Foundation.
Funders:
Funding AgencyGrant Number
Ginger and Ted JenkinsUNSPECIFIED
Mettler Autism FundUNSPECIFIED
Stanley FoundationUNSPECIFIED
Subject Keywords:cytokine; schizophrenia; autism; IL-6; influenza; TNF
Issue or Number:1
DOI:10.1016/S0959-4388(02)00299-4
Record Number:CaltechAUTHORS:20160127-153938256
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160127-153938256
Official Citation:Paul H Patterson, Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness, Current Opinion in Neurobiology, Volume 12, Issue 1, 1 February 2002, Pages 115-118, ISSN 0959-4388, http://dx.doi.org/10.1016/S0959-4388(02)00299-4. (http://www.sciencedirect.com/science/article/pii/S0959438802002994)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64029
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:28 Jan 2016 23:31
Last Modified:10 Nov 2021 23:24

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