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Gap Junctions in Development

Revel, Jean-Paul (1986) Gap Junctions in Development. In: The Cell Surface in Development and Cancer. Developmental Biology: A Comprehensive Synthesis. No.3. Plenum Press , New York, NY, pp. 191-204. ISBN 978-1-4684-5052-1.

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The concept of a multicellular organism as an assemblage of cells that work together harmoniously for the good of the whole organism is well established. Over the past 15 years, however, it has become increasingly clear that the individual cells of multicellular animals are not as self-sufficient and independent of each other as once had been believed. Channels that exist between virtually all neighboring cells permit such widespread intercellular exchanges of low-molecular-weight materials that they must be considered syncytial with respect to small molecules. The specialized areas of the membrane that permit these exchanges are clusters of channels whose permeability is limited only by molecular size of the permeant (Simpson et al., 1977; Flagg-Newton et al., 1979), known collectively as gap junctions. Only in the case of molecules close to the exclusion limit can one detect selectivity (Brink and Dewey, 1980).

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Additional Information:© 1986 Plenum Press. The work cited from the author's laboratory was supported by grants GM-06925 from the NIH, RR-07003 from the BRSG and the Ruddock Foundation.
Funding AgencyGrant Number
Albert Billings Ruddock ProfessorshipUNSPECIFIED
Series Name:Developmental Biology: A Comprehensive Synthesis
Issue or Number:3
Record Number:CaltechAUTHORS:20160128-153653073
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64068
Deposited By: George Porter
Deposited On:28 Jan 2016 23:48
Last Modified:10 Nov 2021 23:25

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