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Early steps in neural crest specification

Barembaum, Meyer and Bronner-Fraser, Marianne (2005) Early steps in neural crest specification. Seminars in Cell and Developmental Biology, 16 (6). pp. 642-646. ISSN 1084-9521. doi:10.1016/j.semcdb.2005.06.006.

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The neural crest is a multipotent cell population that arise at the border of the neural plate and non-neural ectoderm. Studies conducted in a number of model organisms including chickens, frogs, zebrafish and mice have been instrumental in elucidating this molecular mechanisms underlying neural crest formation. Signaling molecules of the Wnt, BMP, and FGF families and their downstream effectors have been shown to mediate neural crest induction. Transcription factors including members of the Snail and SoxE gene families as well as FoxD3, c-Myc and others have been implicated in specification of the neural crest. These studies represent an important step in understanding the regulatory interactions involved in generating this complex and interesting cell type.

Item Type:Article
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Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2005 Elsevier Ltd. Available online 21 July 2005. We would like to thank Paige Fraser, Yun Kee, and Ed Coles for supplying images for the figures.
Subject Keywords: Neural crest; FGF; Wnt; BMP; Slug; SoxE
Issue or Number:6
Record Number:CaltechAUTHORS:20160129-080804452
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Official Citation:Meyer Barembaum, Marianne Bronner-Fraser, Early steps in neural crest specification, Seminars in Cell & Developmental Biology, Volume 16, Issue 6, December 2005, Pages 642-646, ISSN 1084-9521, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64081
Deposited By: Ruth Sustaita
Deposited On:29 Jan 2016 17:11
Last Modified:10 Nov 2021 23:25

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