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Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring

Shi, Limin and Fatemi, Hossein S. and Sidwell, Robert W. and Patterson, Paul H. (2003) Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring. Journal of Neuroscience, 23 (1). pp. 297-302. ISSN 0270-6474. PMCID PMC6742135. https://resolver.caltech.edu/CaltechAUTHORS:20160129-114547570

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Abstract

Maternal viral infection is known to increase the risk for schizophrenia and autism in the offspring. Using this observation in an animal model, we find that respiratory infection of pregnant mice (both BALB/c and C57BL/6 strains) with the human influenza virus yields offspring that display highly abnormal behavioral responses as adults. As in schizophrenia and autism, these offspring display deficits in prepulse inhibition (PPI) in the acoustic startle response. Compared with control mice, the infected mice also display striking responses to the acute administration of antipsychotic (clozapine and chlorpromazine) and psychomimetic (ketamine) drugs. Moreover, these mice are deficient in exploratory behavior in both open-field and novel-object tests, and they are deficient in social interaction. At least some of these behavioral changes likely are attributable to the maternal immune response itself. That is, maternal injection of the synthetic double-stranded RNA polyinosinic-polycytidylic acid causes a PPI deficit in the offspring in the absence of virus. Therefore, maternal viral infection has a profound effect on the behavior of adult offspring, probably via an effect of the maternal immune response on the fetus.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/JNEUROSCI.23-01-00297.2003DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742135PubMed CentralArticle
Additional Information:© 2003 Society for Neuroscience. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received July 26, 2002; revised Oct. 22, 2002; accepted Oct. 24, 2002. This work was supported by a gift from Ginger and Ted Jenkins and a Mettler Autism grant to P.H.P. S.H.F. is a Phyllis and Perry Schwartz National Alliance for Research on Schizophrenia and Depression Established Investigator. R.W.S. was supported by Contract N01-AI-65291 from the Virology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health. We thank D. McDowell and F. Rooks for administrative help, J. Baer for assistance with mice, and L. Tecott for advice on behavioral tests.
Funders:
Funding AgencyGrant Number
Ginger and Ted JenkinsUNSPECIFIED
Mettler Autism FundUNSPECIFIED
NIHN01-AI-65291
Phyllis and Perry Schwartz National Alliance for Research on Schizophrenia and DepressionUNSPECIFIED
National Institute of Allergy and Infectious DiseasesUNSPECIFIED
Subject Keywords:schizophrenia; autism; mental retardation; prepulse inhibition; acoustic startle; open field; novel object; clozapine; chlorpromazine; ketamine; poly(I:C)
Issue or Number:1
PubMed Central ID:PMC6742135
Record Number:CaltechAUTHORS:20160129-114547570
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160129-114547570
Official Citation:Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring Limin Shi, S. Hossein Fatemi, Robert W. Sidwell, and Paul H. Patterson The Journal of Neuroscience, 1 January 2003, 23(1):297-302.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64095
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:29 Jan 2016 21:49
Last Modified:03 Oct 2019 09:34

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