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Gene-Regulatory Interactions in Neural Crest Evolution and Development

Meulemans, Daniel and Bronner-Fraser, Marianne (2004) Gene-Regulatory Interactions in Neural Crest Evolution and Development. Developmental Cell, 7 (3). pp. 291-299. ISSN 1534-5807. doi:10.1016/j.devcel.2004.08.007.

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In this review, we outline the gene-regulatory interactions driving neural crest development and compare these to a hypothetical network operating in the embryonic ectoderm of the cephalochordate amphioxus. While the early stages of ectodermal patterning appear conserved between amphioxus and vertebrates, later activation of neural crest-specific factors at the neural plate border appears to be a vertebrate novelty. This difference may reflect co-option of genetic pathways which conferred novel properties upon the evolving vertebrate neural plate border, potentiating the evolution of definitive neural crest.

Item Type:Article
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Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2004 Cell Press. The authors wish to express their sincerest thanks to Robb Krumlauf, Eric Davidson, Ellen Rothenberg, and Scott Fraser for their invaluable inspiration and feedback, as well as to the anonymous reviewers whose thoughtful suggestions greatly improved the quality of this work. This work was supported by USPHS grant DE13223 and NASA NAG 2-1585 to M.B.-F.
Funding AgencyGrant Number
NASANAG 2-1585
Issue or Number:3
Record Number:CaltechAUTHORS:20160129-132837174
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Official Citation:Daniel Meulemans, Marianne Bronner-Fraser, Gene-Regulatory Interactions in Neural Crest Evolution and Development, Developmental Cell, Volume 7, Issue 3, September 2004, Pages 291-299, ISSN 1534-5807, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64099
Deposited By: Ruth Sustaita
Deposited On:29 Jan 2016 21:44
Last Modified:10 Nov 2021 23:25

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