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Lens Specification Is the Ground State of All Sensory Placodes, from which FGF Promotes Olfactory Identity

Bailey, Andrew P. and Bhattacharyya, Sujata and Bronner-Fraser, Marianne and Streit, Andrea (2006) Lens Specification Is the Ground State of All Sensory Placodes, from which FGF Promotes Olfactory Identity. Developmental Cell, 11 (4). pp. 505-517. ISSN 1534-5807. https://resolver.caltech.edu/CaltechAUTHORS:20160129-134003386

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Abstract

The sense organs of the vertebrate head comprise structures as varied as the eye, inner ear, and olfactory epithelium. In the early embryo, these assorted structures share a common developmental origin within the preplacodal region and acquire specific characteristics only later. Here we demonstrate a fundamental similarity in placodal precursors: in the chick all are specified as lens prior to acquiring features of specific sensory or neurogenic placodes. Lens specification becomes progressively restricted in the head ectoderm, initially by FGF and subsequently by signals derived from migrating neural crest cells. We show that FGF8 from the anterior neural ridge is both necessary and sufficient to promote olfactory fate in adjacent ectoderm. Our results reveal that placode precursors share a common ground state as lens and progressive restriction allows the full range of placodal derivatives to form.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.devcel.2006.08.009DOIArticle
http://www.sciencedirect.com/science/article/pii/S1534580706003558PublisherArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Streit, Andrea0000-0001-7664-7917
Additional Information:© Received: April 7, 2006. Revised: July 15, 2006. Accepted: August 18, 2006. Published: October 2, 2006. We thank Sharon Pudaruth for excellent technical assistance and Claudio Stern for critical comments on the manuscript. This work was funded by grant USPHS DE16459 to M.B.-F., and by a Fight for Sight studentship and a BBSRC project grant (D010659/1) to A.S.
Funders:
Funding AgencyGrant Number
NIHDE16459
Fight for SightUNSPECIFIED
Biotechnology and Biological Sciences Research Council (BBSRC)D010659/1
Subject Keywords:DEVBIO
Issue or Number:4
Record Number:CaltechAUTHORS:20160129-134003386
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160129-134003386
Official Citation:Andrew P. Bailey, Sujata Bhattacharyya, Marianne Bronner-Fraser, Andrea Streit, Lens Specification Is the Ground State of All Sensory Placodes, from which FGF Promotes Olfactory Identity, Developmental Cell, Volume 11, Issue 4, October 2006, Pages 505-517, ISSN 1534-5807, http://dx.doi.org/10.1016/j.devcel.2006.08.009. (http://www.sciencedirect.com/science/article/pii/S1534580706003558)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64100
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:29 Jan 2016 22:07
Last Modified:09 Mar 2020 13:19

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