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Evolutionary conservation of cell migration genes: from nematode neurons to vertebrate neural crest

Kee, Yun and Hwang, Byung Joon and Sternberg, Paul W. and Bronner-Fraser, Marianne (2007) Evolutionary conservation of cell migration genes: from nematode neurons to vertebrate neural crest. Genes and Development, 21 (4). pp. 391-396. ISSN 0890-9369. PMCID PMC1804327. doi:10.1101/gad.1509307.

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Because migratory cells in all animals share common properties, we hypothesized that genetic networks involved in cell migration may be conserved between nematodes and vertebrates. To explore this, we performed comparative genomic analysis to identify vertebrate orthologs of genes required for hermaphrodite-specific neuron (HSN) migration in Caenoryhabditis elegans, and then examined their expression and function in the vertebrate neural crest. The results demonstrate high conservation of regulatory components involved in long-range migrations across diverse species. Although the neural crest is a vertebrate innovation, the results suggest that its migratory properties evolved by utilizing programs already present in the common vertebrate–invertebrate ancestor.

Item Type:Article
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URLURL TypeDescription CentralArticle ItemSupplemental Material
Sternberg, Paul W.0000-0002-7699-0173
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2007 by Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, Received November 7, 2006; revised version accepted January 9, 2007. We thank Samuel Ki for technical assistance and colleagues in the M.B.-F. laboratory for technical advice and discussion. We especially thank Drs. Titus Brown, Scott Fraser, Mihoko Kato, Daniel Meulemans, Ellen Rothenberg, Tatjana Sauka-Spengler, Erich Schwarz, and J.K. Sky Yu for helpful discussions on the manuscript, and Drs. Dominique Alfandari, Tamara Allison, Rik Derynck, Todd Evans, Cees Oudejans, and Richard Harland for sharing the constructs. This work was supported by NIH grants NS36585 and NS051051 (to M.B.-F.); by the Howard Hughes Medical Institute, of which P.W.S. is an Investigator; and by NHGRI Genome Scholar Development and Faculty Transition Award (K22) (to B.J.H.).
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
National Human Genome Research Institute (NHGRI)UNSPECIFIED
Faculty Transition AwardK22
Subject Keywords:Neural crest, cell migration, C. elegans HSN, comparative genomic analysis
Issue or Number:4
PubMed Central ID:PMC1804327
Record Number:CaltechAUTHORS:20160201-085752814
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Official Citation:Kee Y, Hwang BJ, Sternberg PW, Bronner-Fraser M. Evolutionary conservation of cell migration genes: from nematode neurons to vertebrate neural crest. Genes & Development. 2007;21(4):391-396. doi:10.1101/gad.1509307.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64115
Deposited By: Ruth Sustaita
Deposited On:03 Feb 2016 20:56
Last Modified:10 Nov 2021 23:26

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