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Eric Davidson: Steps to A Gene Regulatory Network for Development

Rothenberg, Ellen V. (2016) Eric Davidson: Steps to A Gene Regulatory Network for Development. Developmental Biology, 412 (2). S7-S19. ISSN 0012-1606. PMCID PMC4828313. http://resolver.caltech.edu/CaltechAUTHORS:20160202-124600941

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Abstract

Eric Harris Davidson was a unique and creative intellectual force who grappled with the diversity of developmental processes used by animal embryos and wrestled them into an intelligible set of principles, then spent his life translating these process elements into molecularly definable terms through the architecture of gene regulatory networks. He took speculative risks in his theoretical writing but ran a highly organized, rigorous experimental program that yielded an unprecedentedly full characterization of a developing organism. His writings created logical order and a framework for mechanism from the complex phenomena at the heart of advanced multicellular organism development. This is a reminiscence of intellectual currents in his work as observed by the author through the last 30-35 years of Davidson's life.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.ydbio.2016.01.020DOIArticle
http://www.sciencedirect.com/science/article/pii/S0012160616000154PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828313/PubMed CentralArticle
ORCID:
AuthorORCID
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2016 Elsevier. Available online 26 January 2016. Two members of the Davidson lab in the 1980's and early 1990's who have died since then were close friends and very helpful colleagues to me in those early years. They were founding-generation Davidson lab postdoc Barbara Hough-Evans and computational analyst (and Eric's football teammate) James Moore. Conversations with them during those years gave me considerable insight into research in the group and the currents of intellectual excitement at the time, and I owe them great debts for material included in this reminiscence. My own group's research program was one that benefited from some of the institutions that Eric helped to create, and the intellectual exchange that was an integral part of each of these institutions was in a way the most lasting benefit of all. Great thanks are also due to Andy Cameron for correcting my recollections in a draft of this article. I am grateful for support by an Albert Billings Ruddock Professorship of Biology at Caltech and grants to my lab from NIH.
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Funding AgencyGrant Number
Albert Billings Ruddock ProfessorshipUNSPECIFIED
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PubMed Central ID:PMC4828313
Record Number:CaltechAUTHORS:20160202-124600941
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160202-124600941
Official Citation:Ellen V. Rothenberg, Eric Davidson: Steps to a gene regulatory network for development, Developmental Biology, Volume 412, Issue 2, Supplement, 15 April 2016, Pages S7-S19, ISSN 0012-1606, http://dx.doi.org/10.1016/j.ydbio.2016.01.020. (http://www.sciencedirect.com/science/article/pii/S0012160616000154)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64169
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:02 Feb 2016 22:33
Last Modified:03 Feb 2017 21:10

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