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Budding of alphaviruses

Strauss, James H. and Strauss, Ellen G. and Kuhn, Richard J. (1995) Budding of alphaviruses. Trends in Microbiology, 3 (9). pp. 346-350. ISSN 0966-842X. doi:10.1016/S0966-842X(00)88973-8.

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The icosahedral structures of alphaviruses and of the external shell of the viral nucleocapsid have been defined to very high resolutions, revealing details of the interactions between the glycoproteins to form trimeric spikes, and between the spikes and the nucleocapsid. The structural studies complement biochemical and molecular genetic studies showing that a sequence-specific interaction between the cytoplasmic domains of the glycoproteins and the nucleocapsid drives budding.

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Additional Information:© 1995 Elsevier Science Ltd. Our work is supported by grants AI 10793, AI 20612, AI 33982 and AI 35212 from the NIH.
Funding AgencyGrant Number
NIHAI 10793
NIHAI 20612
NIHAI 33982
NIHAI 35212
Issue or Number:9
Record Number:CaltechAUTHORS:20160203-140411636
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Official Citation:James H. Strass, Ellen G. Strauss, Richard J. Kuhn, Budding of alphaviruses, Trends in Microbiology, Volume 3, Issue 9, September 1995, Pages 346-350, ISSN 0966-842X, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64202
Deposited By: Donna Wrublewski
Deposited On:03 Feb 2016 22:43
Last Modified:10 Nov 2021 23:27

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