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Aura Virus Is a New World Representative of Sindbis-like Viruses

Rümenapf, Tillmann and Strauss, Ellen G. and Strauss, James H. (1995) Aura Virus Is a New World Representative of Sindbis-like Viruses. Virology, 208 (2). pp. 621-633. ISSN 0042-6822. https://resolver.caltech.edu/CaltechAUTHORS:20160203-140411886

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Abstract

Aura virus is an alphavirus present in Brazil and Argentina that is serologically related to Sindbis virus (present throughout the Old World) and to Western equine encephalitis (WEE) virus (present in the Americas). We have previously shown that WEE is a recombinant virus whose glycoproteins and part of whose 3' nontranslated region (NTR) are derived from a Sindbis-like virus, but the remainder of whose genome is derived from Eastern equine encephalitis (EEE) virus. We show here that Aura virus is a Sindbis-like virus that shares considerable organizational and sequence identity with Sindbis virus. Certain nucleotide sequence elements present in Aura RNA that are believed to function as promoters are almost identical to their Sindbis counterparts, repeated elements in the 3' nontranslated region are shared with Sindbis virus, and important antigenic epitopes are conserved between the two viruses. Despite their close relationship, the two viruses have diverged significantly, sharing 73% amino acid sequence identity in the nonstructural proteins and 62% identity in the structural proteins. This is about the same as the identities between EEE and Venezuelan equine encephalitis virus, whose promoter elements, 3' NTRs, and antigenic epitopes have diverged more radically, such that these two viruses are considered to belong to different subgroups. Importantly, the glycoproteins of WEE are more closely related to those of Sindbis than to those of Aura virus. From this we propose that an ancestral Sindbis-like virus present in the Americas (probably South America) diverged 1000-2000 years ago into a lineage that gave rise to Aura virus and a lineage that gave rise to Sindbis virus and to the Sindbis-like parent of WEE. At some time after this divergence, a Slndbis-like virus belonging to the latter lineage was transferred to the Old World where it gave rise to Sindbis viruses distributed throughout the Old World, and in a separate event a Sindbis-like virus belonging to the same lineage underwent recombination with EEE to give rise to WEE.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1006/viro.1995.1193DOIArticle
http://www.sciencedirect.com/science/article/pii/S0042682285711932PublisherArticle
Additional Information:© 1995 Academic Press, Inc. Received December 23, 1994; accepted February 10, 1995. We are grateful to H.-J. Thiel and R. J. Kuhn for their interest and helpful discussion. T.R. was supported by a fellowship from the Deutsche Forschungsgemeinschaft. This work was supported by Grants AI 10793 and AI 20612 from the NIH and Grant DMB-9104054 from the NSF.
Funders:
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)UNSPECIFIED
NIHAI 10793
NIHAI 20612
NSFDMB-9104054
Issue or Number:2
Record Number:CaltechAUTHORS:20160203-140411886
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160203-140411886
Official Citation:Tillmann Rümenapf, Ellen G. Strauss, James H. Strauss, Aura Virus Is a New World Representative of Sindbis-like Viruses, Virology, Volume 208, Issue 2, 20 April 1995, Pages 621-633, ISSN 0042-6822, http://dx.doi.org/10.1006/viro.1995.1193. (http://www.sciencedirect.com/science/article/pii/S0042682285711932)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64203
Collection:CaltechAUTHORS
Deposited By: Donna Wrublewski
Deposited On:03 Feb 2016 22:49
Last Modified:03 Oct 2019 09:35

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