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DNA Electrochemistry through the Base Pairs Not the Sugar−Phosphate Backbone

Liu, Tao and Barton, Jacqueline K. (2005) DNA Electrochemistry through the Base Pairs Not the Sugar−Phosphate Backbone. Journal of the American Chemical Society, 127 (29). pp. 10160-10161. ISSN 0002-7863. doi:10.1021/ja053025c. https://resolver.caltech.edu/CaltechAUTHORS:20160209-123230374

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Abstract

Using intercalated, covalently bound daunomycin as a redox probe, ground state charge transport in DNA films with a perturbation in base pair stacking was examined in comparison with breaks in the sugar−phosphate backbone. While the introduction of one or even two nicks in the sugar−phosphate backbone yields no detectable effect on electron transfer, a CA mismatch significantly attenuates the electron transfer yield. These results confirm that the base pair stack is the pathway for DNA-mediated charge transfer, not the sugar−phosphate backbone.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja053025cDOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja053025cPublisherArticle
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2005 American Chemical Society. Received May 9, 2005. Publication Date (Web): July 1, 2005. We are grateful to NIH (GM61077).
Funders:
Funding AgencyGrant Number
NIHGM61077
Issue or Number:29
DOI:10.1021/ja053025c
Record Number:CaltechAUTHORS:20160209-123230374
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160209-123230374
Official Citation:DNA Electrochemistry through the Base Pairs Not the Sugar−Phosphate Backbone Tao Liu and Jacqueline K. Barton Journal of the American Chemical Society 2005 127 (29), 10160-10161 DOI: 10.1021/ja053025c
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64337
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:09 Feb 2016 21:26
Last Modified:10 Nov 2021 23:29

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