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Probing Nucleic Acid Structure with Shape-Selective Rhodium and Ruthenium Complexes

Jackson, Brian A. and Barton, Jacqueline K. (2001) Probing Nucleic Acid Structure with Shape-Selective Rhodium and Ruthenium Complexes. In: Current Protocols in Nucleic Acid Chemistry. , 6.2.1-6.2.39. https://resolver.caltech.edu/CaltechAUTHORS:20160209-153402366

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Abstract

In this unit, transition metal complexes are used as photochemical probes for the structure of RNA and DNA. The transition metal ion provides a rigid substitutionally inert framework and an octahedral geometry for ligand coordination. The complexes can be constructed to define shapes, symmetries, and functionalities that complement those of the nucleic acid target. Complex formation is easily detected by light-induced nucleic acid cleavage. The modular construction of the complexes makes it possible to generate probes to examine a wide variety of structural characteristics of nucleic acids.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/0471142700.nc0602s00DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/0471142700.nc0602s00/abstractPublisherArticle
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2003 by John Wiley and Sons. The work described here was supported by the NIH (GM33309) and performed by many able graduate students who are referenced as indicated. B.A.J. would also like to acknowledge the NSF for a predoctoral fellowship.
Funders:
Funding AgencyGrant Number
NIHGM33309
NSF Predoctoral FellowshipUNSPECIFIED
Record Number:CaltechAUTHORS:20160209-153402366
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160209-153402366
Official Citation:Jackson, B. A. and Barton, J. K. 2001. Probing Nucleic Acid Structure with Shape-Selective Rhodium and Ruthenium Complexes. Current Protocols in Nucleic Acid Chemistry. 00:6.2:6.2.1–6.2.39.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64350
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:09 Feb 2016 23:50
Last Modified:03 Oct 2019 09:37

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