Jackson, Brian A. and Barton, Jacqueline K. (2001) Probing Nucleic Acid Structure with Shape-Selective Rhodium and Ruthenium Complexes. In: Current Protocols in Nucleic Acid Chemistry. , 6.2.1-6.2.39. https://resolver.caltech.edu/CaltechAUTHORS:20160209-153402366
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Abstract
In this unit, transition metal complexes are used as photochemical probes for the structure of RNA and DNA. The transition metal ion provides a rigid substitutionally inert framework and an octahedral geometry for ligand coordination. The complexes can be constructed to define shapes, symmetries, and functionalities that complement those of the nucleic acid target. Complex formation is easily detected by light-induced nucleic acid cleavage. The modular construction of the complexes makes it possible to generate probes to examine a wide variety of structural characteristics of nucleic acids.
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| Additional Information: | © 2003 by John Wiley and Sons. The work described here was supported by the NIH (GM33309) and performed by many able graduate students who are referenced as indicated. B.A.J. would also like to acknowledge the NSF for a predoctoral fellowship. | |||||||||
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| Record Number: | CaltechAUTHORS:20160209-153402366 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160209-153402366 | |||||||||
| Official Citation: | Jackson, B. A. and Barton, J. K. 2001. Probing Nucleic Acid Structure with Shape-Selective Rhodium and Ruthenium Complexes. Current Protocols in Nucleic Acid Chemistry. 00:6.2:6.2.1–6.2.39. | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 64350 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | George Porter | |||||||||
| Deposited On: | 09 Feb 2016 23:50 | |||||||||
| Last Modified: | 03 Oct 2019 09:37 |
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