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An Electrochemical Probe of DNA Stacking in an Antisense Oligonucleotide Containing a C3’-endo-Locked Sugar

Boon, Elizabeth M. and Barton, Jacqueline K. and Pradeepkumar, Pushpangadan I. and Isaksson, Johan and Petit, Catherine and Chattopadhyaya, Jyoti (2002) An Electrochemical Probe of DNA Stacking in an Antisense Oligonucleotide Containing a C3’-endo-Locked Sugar. Angewandte Chemie International Edition, 41 (18). pp. 3402-3405. ISSN 1433-7851. https://resolver.caltech.edu/CaltechAUTHORS:20160210-154230344

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Abstract

The preferred base-stacking orientation of a conformationally constrained nucleotide (3′-endo-locked) within DNA/DNA and DNA/RNA duplexes (see picture) was probed by charge transport through DNA-modified gold electrode surfaces. The conformation of the sugar is seen to sensitively determine the local stacking of the duplex. These results illustrate the utility of DNA-mediated charge transport through DNA-modified surfaces in characterizing small perturbations in DNA stacking and structure.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/1521-3773(20020916)41:18<3402::AID-ANIE3402>3.0.CO;2-6DOIArticle
http://onlinelibrary.wiley.com/wol1/doi/10.1002/1521-3773%2820020916%2941:18%3C3402::AID-ANIE3402%3E3.0.CO;2-6/abstractPublisherArticle
ORCID:
AuthorORCID
Boon, Elizabeth M.0000-0003-1891-839X
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2002 WILEY-VCH Verlag GmbH & Co. Received: March 14, 2002. Article first published online: 16 Sep 2002. This work was supported bythe National Institutes of Health (GM61077 to J.K.B.), the Swedish Natural Science Research Council (N.F.R.), the Swedish Research Council for Engineering Sciences (T.F.R.), and the Stiftelsen för Strategisk forskning (J.C.).
Funders:
Funding AgencyGrant Number
NIHGM61077
Swedish Natural Science Research CouncilUNSPECIFIED
Swedish Research Council for Engineering SciencesUNSPECIFIED
Stiftelsen för Strategisk forskningUNSPECIFIED
Issue or Number:18
Record Number:CaltechAUTHORS:20160210-154230344
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160210-154230344
Official Citation:Boon, E. M., Barton, J. K., Pradeepkumar, P. I., Isaksson, J., Petit, C. and Chattopadhyaya, J. (2002), An Electrochemical Probe of DNA Stacking in an Antisense Oligonucleotide Containing a C3′-endo-Locked Sugar. Angew. Chem. Int. Ed., 41: 3402–3405. doi: 10.1002/1521-3773(20020916)41:18<3402::AID-ANIE3402>3.0.CO;2-6
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64391
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:19 Feb 2016 20:48
Last Modified:03 Oct 2019 09:37

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