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Excess FoxG1 causes overgrowth of the neural tube

Ahlgren, Sara and Vogt, Peter and Bronner-Fraser, Marianne (2003) Excess FoxG1 causes overgrowth of the neural tube. Journal of Neurobiology, 57 (3). pp. 337-349. ISSN 0022-3034. doi:10.1002/neu.10287.

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The winged helix transcription factor FoxG1 (Bf-1, qin) plays multiple roles in the development of the telencephalon, with different parts of the protein affecting either proliferation or differentiation. We examined the consequences of over-expression, via retroviral expression, of FoxG1 on the growth of different regions of the chicken brain. Excess expression of FoxG1 caused a thickening of the neuroepithelium, and ultimately large outgrowths of the telencephalon and mesencephalon. In contrast, the myelencephalon appeared unaffected, exhibiting normal apoptosis and growth characteristics. A DNA binding defective form of FoxG1 did not exhibit these abnormalities, suggesting that these effects are due to FoxG1's function as a transcriptional repressor. To examine the means by which excess FoxG1caused overgrowth of the brain, we examined alterations in cell proliferation and death. No increase in proliferation was noted in any portion of the neural tube, rather a significant decrease in neuroepithelial apoptosis was seen. These results demonstrate a previously unrecognized role for winged helix factors in the regulation of neural cell apoptosis.

Item Type:Article
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Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2003 Wiley Periodicals, Inc. Received 3 April 2003; accepted 8 June 2003. SCA was supported by an American Heart Association postdoctoral fellowship, award #1168-F11. This is TSRI Manuscript Number 15551-MEM. Contract grant sponsor: American Heart Association; contract grant number: 1168-F11 (S.C.A.). Contract grant sponsor: March of Dimes; contract grant number: 6-FY02-134 (S.C.A.). Contract grant sponsor: NIH; contract grant number: USPHS NS36585 (M.B.F.). Contract grant sponsor: NIH; contract grant number: CA79616 (P.V.).
Funding AgencyGrant Number
American Heart Association1168-F11
March of Dimes6-FY02-134
Subject Keywords:FoxG1; chick; telencephalon; mesencephalon; cell death; growth control
Issue or Number:3
Record Number:CaltechAUTHORS:20160212-082729250
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Official Citation:Ahlgren, S., Vogt, P. and Bronner-Fraser, M. (2003), Excess FoxG1 causes overgrowth of the neural tube. J. Neurobiol., 57: 337–349. doi: 10.1002/neu.10287
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64451
Deposited By: Ruth Sustaita
Deposited On:18 Feb 2016 00:04
Last Modified:10 Nov 2021 23:31

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