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Behavioral Stress and Tumor Progression

Montgomery, Jennifer P. and Patterson, Paul H. (2006) Behavioral Stress and Tumor Progression. Anticancer Research, 26 (2A). pp. 1189-1192. ISSN 0250-7005.

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Background: A number of laboratories have reported a possible link between behavioral stress and cancer progression. Previously published findings demonstrated a stress-induced increase in tumor growth of implanted lymphosarcoma in C3H mice. Here, two mouse models were utilized to investigate whether stress alters the growth of solid tumors. Materials and Methods: We developed a stress paradigm that involves alternating established stressors for 12 days. FVB mice implanted with melanoma were subjected to this stress protocol. We also attempted to duplicate Riley's finding. Results: Our stress paradigm markedly increased serum corticosterone levels and thymus involution. No alteration in the growth of the melanoma tumors was observed. There was also no significant effect on lymphosarcoma progression using either our own or Riley's stress protocol. Conclusion: Under the conditions used in this study, strong behavioral stress did not influence tumor progression.

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Additional Information:© 2006 International Institute of Anticancer Research. Received December 9, 2005. Accepted December 22, 2005. We thank Dr. Sylvian Bauer, Dr. Benjamin Deverman and Dr. Fraser Moss for their helpful comments on the manuscript. This work was supported by the Kenneth and Eileen Norris Foundation and the Dana Foundation Clinical Hypotheses in Neuroscience Research, U.S.A.
Funding AgencyGrant Number
Kenneth and Eileen Norris FoundationUNSPECIFIED
Dana Foundation Clinical Hypotheses in Neuroscience ResearchUNSPECIFIED
Subject Keywords:Melanoma, lymphosarcoma, corticosterone, thymus involution, stress
Issue or Number:2A
Record Number:CaltechAUTHORS:20160212-095212086
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Official Citation:JENNIFER P. MONTGOMERY and PAUL H. PATTERSON Behavioral Stress and Tumor Progression Anticancer Res March-April 2006 26 (2A) 1189-1192
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64463
Deposited By: Ruth Sustaita
Deposited On:19 Feb 2016 20:34
Last Modified:03 Oct 2019 09:38

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