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Identification of candidate secreted factors involved in trigeminal placode induction

McCabe, Kathryn L. and Shiau, Celia E. and Bronner-Fraser, Marianne (2007) Identification of candidate secreted factors involved in trigeminal placode induction. Developmental Dynamics, 236 (10). pp. 2925-2935. ISSN 1058-8388. doi:10.1002/dvdy.21325. https://resolver.caltech.edu/CaltechAUTHORS:20160212-105800028

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Abstract

Cranial ectodermal placodes are critical for normal development of the peripheral nervous system of the head. However, many aspects of the molecular and tissue interactions involved in their induction have yet to be elucidated. The trigeminal placode is induced by an unidentified secreted factor(s) from the dorsal neural tube. To determine candidates that may be involved in this induction process, we have performed reverse transcriptase-polymerase chain reaction (RT-PCR) and whole-mount in situ hybridization to screen for receptors expressed by uninduced presumptive trigeminal level ectoderm. We have found that receptors for fibroblast growth factors, insulin-like growth factors, platelet-derived growth factors, Sonic hedgehog, the transforming growth factor-beta superfamily, and Wnts all are expressed in patterns consistent with a role in trigeminal placode formation. This RT-PCR screen for candidate receptors expressed in presumptive trigeminal ectoderm is the first systematic screen to identify potential interactions underlying induction of the trigeminal placode and represents a critical step for understanding this complex process.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/dvdy.21325DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/dvdy.21325/abstractPublisherArticle
ORCID:
AuthorORCID
Shiau, Celia E.0000-0002-9347-9158
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2007 Wiley-Liss, Inc. Accepted 13 August 2007; published online 14 September 2007. Funded by NIH. Grant Number: R01 DE16459. We thank Samuel Ki and Andrea Manzo for technical assistance.
Funders:
Funding AgencyGrant Number
NIHR01 DE16459
Subject Keywords:trigeminal placode induction; FGF; IGF; PDGF; Shh; TGFβ superfamily; Wnt
Issue or Number:10
DOI:10.1002/dvdy.21325
Record Number:CaltechAUTHORS:20160212-105800028
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160212-105800028
Official Citation:McCabe, K. L., Shiau, C. E. and Bronner-Fraser, M. (2007), Identification of candidate secreted factors involved in trigeminal placode induction. Dev. Dyn., 236: 2925–2935. doi: 10.1002/dvdy.21325
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64474
Collection:CaltechAUTHORS
Deposited By: Melissa Ray
Deposited On:19 Feb 2016 20:18
Last Modified:10 Nov 2021 23:31

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