McCabe, Kathryn L. and Shiau, Celia E. and Bronner-Fraser, Marianne (2007) Identification of candidate secreted factors involved in trigeminal placode induction. Developmental Dynamics, 236 (10). pp. 2925-2935. ISSN 1058-8388. doi:10.1002/dvdy.21325. https://resolver.caltech.edu/CaltechAUTHORS:20160212-105800028
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Abstract
Cranial ectodermal placodes are critical for normal development of the peripheral nervous system of the head. However, many aspects of the molecular and tissue interactions involved in their induction have yet to be elucidated. The trigeminal placode is induced by an unidentified secreted factor(s) from the dorsal neural tube. To determine candidates that may be involved in this induction process, we have performed reverse transcriptase-polymerase chain reaction (RT-PCR) and whole-mount in situ hybridization to screen for receptors expressed by uninduced presumptive trigeminal level ectoderm. We have found that receptors for fibroblast growth factors, insulin-like growth factors, platelet-derived growth factors, Sonic hedgehog, the transforming growth factor-beta superfamily, and Wnts all are expressed in patterns consistent with a role in trigeminal placode formation. This RT-PCR screen for candidate receptors expressed in presumptive trigeminal ectoderm is the first systematic screen to identify potential interactions underlying induction of the trigeminal placode and represents a critical step for understanding this complex process.
Item Type: | Article | |||||||||
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Additional Information: | © 2007 Wiley-Liss, Inc. Accepted 13 August 2007; published online 14 September 2007. Funded by NIH. Grant Number: R01 DE16459. We thank Samuel Ki and Andrea Manzo for technical assistance. | |||||||||
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Subject Keywords: | trigeminal placode induction; FGF; IGF; PDGF; Shh; TGFβ superfamily; Wnt | |||||||||
Issue or Number: | 10 | |||||||||
DOI: | 10.1002/dvdy.21325 | |||||||||
Record Number: | CaltechAUTHORS:20160212-105800028 | |||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160212-105800028 | |||||||||
Official Citation: | McCabe, K. L., Shiau, C. E. and Bronner-Fraser, M. (2007), Identification of candidate secreted factors involved in trigeminal placode induction. Dev. Dyn., 236: 2925–2935. doi: 10.1002/dvdy.21325 | |||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
ID Code: | 64474 | |||||||||
Collection: | CaltechAUTHORS | |||||||||
Deposited By: | Melissa Ray | |||||||||
Deposited On: | 19 Feb 2016 20:18 | |||||||||
Last Modified: | 10 Nov 2021 23:31 |
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